Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이근용 | - |
dc.date.accessioned | 2018-03-28T05:35:29Z | - |
dc.date.available | 2018-03-28T05:35:29Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | Colloids and surfaces Biointerfaces, 2014, 123, P.679-684 | en_US |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776514005372 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/53275 | - |
dc.description.abstract | In tissue engineering, the nanoscale topography of the substrate is important, because transplanted cells can recognize and respond to topographical patterns, allowing control of gene expression and tissue formation. In this study, we hypothesized that the height of cell-adhesive nanoposts could regulate cell phenotype. Nano-patterned surfaces were generated via self-assembly of polystyrene-b-poly(ethylene oxide)/dodecylbenzenesulfonic acid (PS-b-PEO/DBSA) complex systems. The height of PS nanoposts, which are considered to be cell-adhesion domains, was varied from 11 to 43 nm, while nanopost size and the center-to-center distance between nanoposts were kept constant. Adhesion, growth, and differentiation of mouse preosteoblasts (MC3T3-E1) cultured on the nano-patterned surfaces were significantly influenced by nanopost height. This approach therefore holds great promise for the design of biomedical devices, as well as tissue engineering scaffolds. (C) 2014 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI13C1940). J.W.L. and S.H.K. would also like to acknowledge financial support from the Inha University Research Grant. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | Nano-patterned surface | en_US |
dc.subject | Nanopost | en_US |
dc.subject | Block copolymer | en_US |
dc.subject | Self-assembly | en_US |
dc.subject | Osteoblast | en_US |
dc.subject | Tissue engineering | en_US |
dc.title | The height of cell-adhesive nanoposts generated by block copolymer/surfactant complex systems influences the preosteoblast phenotype | en_US |
dc.title.alternative | surfactant complex systems influences the preosteoblast phenotype | en_US |
dc.type | Article | en_US |
dc.relation.volume | 123 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2014.10.006 | - |
dc.relation.page | 679-684 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Jeong, Eun-Ju | - |
dc.contributor.googleauthor | Lee, Jin-Wook | - |
dc.contributor.googleauthor | Kwark, Young-Je | - |
dc.contributor.googleauthor | Kim, Seung-Hyun | - |
dc.contributor.googleauthor | Lee, Kuen-Yong | - |
dc.relation.code | 2014027563 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | leeky | - |
dc.identifier.orcid | http://orcid.org/0000-0002-5759-5952 | - |
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