Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용석 | - |
dc.date.accessioned | 2018-03-27T00:46:52Z | - |
dc.date.available | 2018-03-27T00:46:52Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | PLOS ONE, 9권, 10호, 논문번호 e109253 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://doi.org/10.1371/journal.pone.0109253 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/52818 | - |
dc.description.abstract | Functional consequences to which vertebrate GATA transcription factors contribute in the adult brain remain largely an open question. The present study examines how human GATA-1 and GATA-2 (hGATA-1 and hGATA-2) are linked to neuronal differentiation and depressive behaviors in rats. We investigated the effects of adeno-associated viral expression of hGATA-1 and hGATA-2 (AAV-hGATA1 and AAV-hGATA2) in the dentate gyrus (DG) of the dorsal hippocampus on dendrite branching and spine number. We also examined the influence of AAV-hGATA1 and AAV-hGATA2 infusions into the dorsal hippocampus on rodent behavior in models of depression. Viral expression of hGATA-1 and hGATA-2 cDNA in rat hippocampal neurons impaired dendritic outgrowth and spine formation. Moreover, viral-mediated expression of hGATA-1 and hGATA-2 in the dorsal hippocampus caused depressive-like deficits in the forced swim test and learned helplessness models of depression, and decreased the expression of several synapse-related genes as well as spine number in hippocampal neurons. Conversely, shRNA knockdown of GATA-2 increased synapse-related gene expression, spine number, and dendrite branching. The results demonstrate that hGATA-1 and hGATA-2 expression in hippocampus is sufficient to cause depressive like behaviors that are associated with reduction in spine synapse density and expression of synapserelated genes. | en_US |
dc.description.sponsorship | National Research Foundation grant of Korea - Korea government | en_US |
dc.language.iso | en | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE, 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA | en_US |
dc.subject | ANTIDEPRESSANT ACTIONS | en_US |
dc.subject | DENDRITIC SPINES | en_US |
dc.subject | DENDRITIC SPINES | en_US |
dc.subject | PROMOTER | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | PLASTICITY | en_US |
dc.subject | BRAIN | en_US |
dc.subject | IDENTIFICATION | en_US |
dc.subject | PLASTICITY | en_US |
dc.subject | REGULATOR | en_US |
dc.title | Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1371/journal.pone.0109253 | - |
dc.identifier.doi | 10.1371/journal.pone.0109253 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | PLOS ONE | - |
dc.contributor.googleauthor | ChoiChoi, Miyeon Miyeon | - |
dc.contributor.googleauthor | WangWang, Sung Eun Sung Eun | - |
dc.contributor.googleauthor | KoKo, Seung Yeon Seung Yeon | - |
dc.contributor.googleauthor | KangKang, Hyo Jung Hyo Jung | - |
dc.contributor.googleauthor | ChaeChae, Seung Yeun Seung Yeun | - |
dc.contributor.googleauthor | LeeLee, Seung Hoon Seung Hoon | - |
dc.contributor.googleauthor | KimKim, Yong-Seok Yong-Seok | - |
dc.contributor.googleauthor | DumanDuman, Ronald S. Ronald S | - |
dc.contributor.googleauthor | SonSon, Hyeon Hyeon | - |
dc.relation.code | 2014037807 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yongsk | - |
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