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Visible Light-Induced Aromatic Difluoroalkylation

Title
Visible Light-Induced Aromatic Difluoroalkylation
Author
조은진
Keywords
aromatics; difluoroalkylation; heteroaromatics; iridium; visible light; COPPER-MEDIATED DIFLUOROMETHYLATION; C-H ACTIVATION; PHOTOREDOX CATALYSIS; F BOND; TRIFLUOROMETHYLATION; HETEROARENES; IODIDES; ALKENES; ARYL; PERFLUOROALKYLATION
Issue Date
2014-09
Publisher
WILEY-V C H VERLAG GMBH
Citation
Photocatalysis in Organic Synthesis, 2014, 356(13), P.2741-2748
Abstract
Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2?bromo?2,2?difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac?[Ir(ppy)3] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2?containing aromatics, demonstrating the synthetic utility of the present method.
URI
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201400542http://hdl.handle.net/20.500.11754/52705
ISSN
1615-4150; 1615-4169
DOI
10.1002/adsc.201400542
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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