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dc.contributor.author최호순-
dc.date.accessioned2018-03-26T03:33:15Z-
dc.date.available2018-03-26T03:33:15Z-
dc.date.issued2014-05-
dc.identifier.citationSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2014, 49(5), p.604-610en_US
dc.identifier.issn0036-5521-
dc.identifier.issn1502-7708-
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/00365521.2013.878382-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/52221-
dc.description.abstractBackground. In neurophysiological studies, P300, is well known for reflecting early cognitive impairment in minimal hepatic encephalopathy (MHE). Although P300 is investigated extensively, other early event-related potential (ERP) parameters have not been studied in MHE. Methods. The subjects were 21 adult cirrhotic patients without clinical encephalopathy and 29 normal controls. For neuropsychological testing, number connection tests, A and B (NCT-A, NCT-B), the line tracing test, the serial dotting test (SDT), and the digit symbol test (DST) were performed. For ERP testing, auditory oddball paradigms were used. The N100, P200, N200, and P300 parameters were measured. Results. Cirrhosis had longer neuropsychological performance scores on NCT-A, SDT, and DST than the control group. In neurophysiological test, cirrhotic patients showed longer latencies for N100, P200, N200, and P300 than the control group. Although P300 alteration was not seen in patients without MHE compared to the control group (325.4 +/- 43.3 vs. 345.21 +/- 35.1, p = 0.25), N200 latency was significantly prolonged in cirrhotic patients without MHE compared to the healthy group (242.1 +/- 30.3 vs. 259.58 +/- 33.3, p = 0.006). N200 also showed good correlation with psychometric hepatic encephalopathy score and critical flicker frequency. Conclusions. N200 is a useful tool for assessing early changes of cognitive dysfunction in cirrhosis. It suggests that slower auditory cortical processing is the first sign of cerebral deterioration in patients with hepatic encephalopathy.en_US
dc.description.sponsorshipThe authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. This work was supported by the research fund of Hanyang University (HY-2012-C).en_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCARE, TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLANDen_US
dc.subjectEvent-related potentialsen_US
dc.subjecthepatic encephalopathyen_US
dc.subjectminimal hepatic encephalopathyen_US
dc.subjectN200en_US
dc.subjectP300en_US
dc.subjectpsychometric hepatic encephalopathy scoreen_US
dc.titleProlonged N200 is the early neurophysiologic change in the patient with minimal hepatic encephalopathyen_US
dc.typeArticleen_US
dc.relation.volume49-
dc.identifier.doi10.3109/00365521.2013.878382-
dc.relation.page604-610-
dc.relation.journalSCANDINAVIAN JOURNAL OF GASTROENTEROLOGY-
dc.contributor.googleauthorMoon, Jin-Hwa-
dc.contributor.googleauthorJun, Dae Won-
dc.contributor.googleauthorYum, Myung-Kul-
dc.contributor.googleauthorLee, Kang Nyeong-
dc.contributor.googleauthorLee, Hang Lak-
dc.contributor.googleauthorLee, Oh Young-
dc.contributor.googleauthorYoon, Byung Chul-
dc.contributor.googleauthorChoi, Ho Soon-
dc.contributor.googleauthorHahm, Joon Soo-
dc.contributor.googleauthorSeol, In Joon-
dc.relation.code2014039148-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhschoi96-
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COLLEGE OF MEDICINE[S](의과대학) > ETC
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