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The application of different appendicular skeletal muscle cutoff points and research definitions associated with health-related quality of life in Korean older people: data from KNHANES 2008-2011

Title
The application of different appendicular skeletal muscle cutoff points and research definitions associated with health-related quality of life in Korean older people: data from KNHANES 2008-2011
Author
황환식
Keywords
Sarcopenia; Korean; Older people
Issue Date
2014-12
Publisher
BIOMED CENTRAL LTD
Citation
BMC GERIATRICS, 권: 14,pp.144 -
Abstract
Background: This study was conducted to determine the prevalence of a low appendicular skeletal muscle index (ASMI) using three cut-off points (mean ASMI-2SD of a gender-specific young reference group (aged 18-39 years), mean ASMI-1SD of a gender-specific young reference group, and the lower 20 percentile value of a gender-specific older group (aged >= 65 years)) in Korean older people and the relationship between ASMI and subjective health-related quality of life.Methods: This study utilized data acquired during the Korean National Health and Nutrition Examination Survey (KNHANES) from 2008-2011. Dual-energy X-ray absorptiometry body compositional data was obtained from a subsample of 6538 subjects (men 2804, women 3734) aged 18-39 and 4413 subjects (men 1872, women 2541) aged 65 years and older. The three definitions of low appendicular skeletal muscle and the EQ-5D-3 L-Korean descriptive system were applied to Korean older people.Results: For the ASMI cutoff points used, in men, the three cutoff points were ASMI 2SD (6.09 kg/m(2)), ASMI 20 (6.48 kg/m(2)), and ASMI 1SD (6.95 kg/m(2)). In women, ASMI 2SD (4.38 kg/m(2)) was the lowest, followed by ASMI 1SD (4.96 kg/m(2)) and ASMI 20 (5.33 kg/m(2)). Proportions of older subjects with a low ASMI using the three cutoff points were 9.7% (ASMI 2SD) and 40.9% (ASMI 1SD) in men, and 0.7% (ASMI 2SD) and 7.4% (ASMI 1SD) in women. By multivariate ordinal logistic regression analysis, men with a low ASMI had significantly high odd ratios for the three domains of mobility (p < 0.001), self-care (p = 0.005), and usual activities (p = 0.004) among the five domains of the EQ-5D and EQ-5D index (p = 0.010).Conclusions: The ASMI 2SD cut-off points for older Koreans, 6.09 kg/m(2) for men and 4.38 kg/m(2) for women, resulted in low prevalences of a low ASM, that is, 9.7% for men and 0.7% for women, and showed low clinical usefulness due to very low determined prevalence in women. Hence, we suggest that the cut-off point of the lowest 20% of Korean older people (men: 6.48 kg/m(2), women; 5.33 kg/m(2)) be used for older Koreans.
URI
https://bmcgeriatr.biomedcentral.com/articles/10.1186/1471-2318-14-144http://hdl.handle.net/20.500.11754/51979
ISSN
1471-2318
DOI
10.1186/1471-2318-14-144
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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