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Background F-18-FDG uptake in positron emission mammography (PEM): Correlation with mammographic density and background parenchymal enhancement in breast MRI

Title
Background F-18-FDG uptake in positron emission mammography (PEM): Correlation with mammographic density and background parenchymal enhancement in breast MRI
Author
구혜령
Keywords
Background F-18-FDG uptake; PEM (positron emission mammography); Mammographic density; Breast MRI; Background parenchymal enhancement (BPE); CANCER RISK; TISSUE; AGE; WOMEN
Issue Date
2013-10
Publisher
ELSEVIER IRELAND LTD
Citation
EUROPEAN JOURNAL OF RADIOLOGY, 2013, 82(10), P.1738-1742
Abstract
AbstractWe aimed to determine whether background 18F-FDG uptake in positron emission mammography (PEM) was related to mammographic density or background parenchymal enhancement in breast MRI.MethodsWe studied a total of 52 patients (mean age, 50.9 years, 26 premenopausal, 26 postmenopausal) with newly diagnosed breast cancer who underwent 18F-FDG PEM (positron emission mammography), conventional mammography and breast MRI. The background mean 18F-FDG uptake value on PEM was obtained by drawing a user-defined region of interest (ROI) in a normal area of the contralateral breast. We reviewed the mammography retrospectively for overall breast density of contralateral breast according to the four-point scale (grade 1?4) of the Breast Imaging Reporting and Data System (BI-RADS) classification. The background parenchymal enhancement of breast MRI was classified as minimal, mild, moderate, or marked. All imaging findings were interpreted by two readers in consensus without knowledge of image findings of other modalities.ResultsMultiple linear regression analysis revealed a significant correlation between background 18F-FDG uptake on PEM and mammographic density after adjustment for age and menopausal status (P < 0.01), but not between background 18F-FDG uptake on PEM and background parenchymal enhancement on MRI.ConclusionBackground 18F-FDG uptake on PEM significantly increases as mammographic density increases. Background parenchymal enhancement in breast MRI was not an independent predictor of the background 18F-FDG uptake on PEM unlike mammographic density.
URI
https://ac.els-cdn.com/S0720048X13002611/1-s2.0-S0720048X13002611-main.pdf?_tid=6b77e4e4-4d05-4601-905d-b5794c9727a1&amp;acdnat=1520859678_4741fa0988be02b7dac5471fcfd4edachttp://hdl.handle.net/20.500.11754/51692
ISSN
0720-048X
DOI
10.1016/j.ejrad.2013.05.016
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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