Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
- Title
- Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
- Author
- 황정혜
- Keywords
- Coxsackievirus; missed abortion; fetal anomaly
- Issue Date
- 2014-04
- Publisher
- YONSEI UNIV COLL MEDICINE, 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
- Citation
- YONSEI MEDICAL JOURNAL; NOV 1 2014, 55, 6, p1562-p1567
- Abstract
- Purpose: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. Materials and Methods: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tern delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confimied by genome sequencing. Hernesviruses were detected by PCR. Results: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. Conclusion: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.3349/ymj.2014.55.6.1562http://hdl.handle.net/20.500.11754/51669
- ISSN
- 0513-5796
- DOI
- 10.3349/ymj.2014.55.6.1562
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
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