Retinal Nerve Fiber Layer Volume Measurements in Healthy Subjects Using Spectral Domain Optical Coherence Tomography
- Title
- Retinal Nerve Fiber Layer Volume Measurements in Healthy Subjects Using Spectral Domain Optical Coherence Tomography
- Author
- 엄기방
- Keywords
- retinal nerve fiber layer; volume; spectral domain; optical coherence tomography
- Issue Date
- 2014-10
- Publisher
- Lippincott Williams and Wilkins
- Citation
- Journal of glaucoma v.23 no.8, 2014년, pp.567 - 573
- Abstract
- Purpose: To report retinal nerve fiber layer (RNFL) volume measurement using spectral domain optical coherence tomography (SD-OCT). We determined the characteristics and effecting factors of the RNFL volume in healthy eyes.Methods: Eighty-six eyes from 86 healthy volunteers were included. All participants underwent 3D-disc scanning using SD-OCT. We developed a computer program using Matlab software to extract RNFL thickness values from colored topographic RNFL thickness map. Total average, quadrant, and clock-hour RNFL volume were automatically calculated between 2.5 and 5 mm diameter circles using the length, width, and height of each pixel derived from the RNFL thickness map.Results: The mean total RNFL volume was 1.478±0.124 mm3 and RNFL volume profiles showed double-hump patterns. RNFL volumes of superior and inferior quadrants were significantly greater than those of temporal and nasal quadrants (all P<0.001). A strong correlation existed between RNFL volume and conventional circumpapillary RNFL thickness measured by built-in software (R=0.895 to 0.972). Image quality and age were associated with RNFL volume measurement.Conclusions: RNFL volume measurement from RNFL thickness map analysis provides an alternative approach to characterizing and evaluating RNFL. RNFL volume measurement may be valuable for the objective and quantitative evaluation of 3-dimensional RFNL changes.
- URI
- http://ovidsp.tx.ovid.com/sp-3.28.0a/ovidweb.cgi?&S=NEOIFPAFCDDDLEMGNCFKCFIBFNMGAA00&Link+Set=S.sh.2.14.22.24.28.32%7c14%7csl_10http://hdl.handle.net/20.500.11754/51583
- ISSN
- 1057-0829; 1536-481X
- DOI
- 10.1097/IJG.0b013e3182948673
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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