Chemoradiotherapy for Extrahepatic Bile Duct Cancer with Gross Residual Disease after Surgery
- Title
- Chemoradiotherapy for Extrahepatic Bile Duct Cancer with Gross Residual Disease after Surgery
- Author
- 박혜진
- Keywords
- Extrahepatic bile duct cancer; chemoradiotherapy; ailure pattern; R2 resection
- Issue Date
- 2014-11
- Publisher
- INT INST ANTICANCER RESEARCH, EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE
- Citation
- ANTICANCER RESEARCH, 권: 34, 호: 11, 페이지: 6685-6690
- Abstract
- Background: The purpose of the present study was to analyze the outcome of chemoradiotherapy for extrahepatic bile duct (EHBD) cancer patients with gross residual disease after surgical resection. Patients and Methods: We retrospectively analyzed 30 patients with EHBD adenocarcinoma who underwent chemoradiotherapy after palliative resection (R2 resection). Postoperative radiotherapy was delivered to the tumor bed including residual tumor and regional lymph nodes (range=40-55.8 Gy). Most patients underwent chemoradiotherapy concurrently with 5-fluorouracil (5-FU) or gemcitabine. Results: The 2-year locoregional progression-free, distant metastasis-free and overall survival rates were 33.3%, 42.4% and 44.5%, respectively. High radiation dose >= 50 Gy had a marginally significant impact on superior locoregional progression-free survival compared to 40 Gy (p=0.081). One patient developed grade 3 late gastrointestinal toxicity. Conclusion: Adjuvant chemoradiotherapy for EHBD cancer patients with gross residual disease after surgery was well-tolerated. There could be a chance for durable locoregional control and even long-term survival in selected patients.
- URI
- http://ar.iiarjournals.org/content/34/11/6685.shorthttp://hdl.handle.net/20.500.11754/51573
- ISSN
- 0250-7005; 1791-7530
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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