51 30

Necroptosis in Liver and Pancreatic Diseases

Title
Necroptosis in Liver and Pancreatic Diseases
Other Titles
간, 췌장 질환에서 Necroptosis
Author
전대원
Keywords
Cell death; Necroptosis; Necrosis; Receptor-interacting protein kinase; Tumor necrosis factor-alpha
Issue Date
2014-11
Publisher
The Korean Society Of Gastroenterology
Citation
대한소화기학회지, 권: 64, 호: 4, 페이지: 182-188
Abstract
Cell death is an integral part of life of an organism that is necessary to maintain organs and tissues. Apoptosis, autophagy, and necrosis were noted as three morphologically distinct types of cell death. Apoptosis is a well identified process that is driven by programmed molecular mechanism. Until now, the investigators believed that necrosis was not a programmed molecular event. However, recently, an alternative death pathway called 'necroptosis' was delineated and proposed as a form of 'programmed necrosis'. According to the recent recommendations by the Nomenclature Committee of Cell Death, this term denotes necrotic cell death dependent on receptor-interacting protein kinase (RIPK3). Its role in a variety of diseases, such as ischemia-perfusion injury, infection, inflammatory bowel disease, pancreatitis, steatohepatitis etc., is being elucidated. Necroptosis is currently attracting the attention of the scientific community. Herein we discuss the clinical implications and the role of necroptosis in gastrointestinal tract focusing on liver and pancreatic diseases.
URI
https://www.synapse.koreamed.org/search.php?where=aview&id=10.4166/kjg.2014.64.4.182&code=0028KJG&vmode=FULLhttp://hdl.handle.net/20.500.11754/51551
ISSN
1598-9992
DOI
10.4166/kjg.2014.64.4.182
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
kjg-64-182.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE