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Necroptosis: An emerging type of cell death in liver diseases

Title
Necroptosis: An emerging type of cell death in liver diseases
Author
전대원
Keywords
Necroptosis; Programmed necrosis; Apoptosis; Cell death; Liver disease
Issue Date
2014-11
Publisher
BAISHIDENG PUBLISHING GROUP INC, 8226 REGENCY DR, PLEASANTON, CA 94588 USA
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, 권: 20, 호: 35, 페이지: 12526-12532
Abstract
Cell death has been extensively evaluated for decades and it is well recognized that pharmacological interventions directed to inhibit cell death can prevent significant cell loss and can thus improve an organ' s physiological function. For long, only apoptosis was considered as a sole form of programmed cell death. Recently necroptosis, a RIP1/RIP3-dependent programmed cell death, has been identified as an apoptotic backup cell death mechanism with necrotic morphology. The evidences of necroptosis and protective effects achieved by blocking necroptosis have been extensively reported in recent past. However, only a few studies reported the evidence of necroptosis and protective effects achieved by inhibiting necroptosis in liver related disease conditions. Although the number of necroptosis initiators is increasing; however, interestingly, it is still unclear that what actually triggers necroptosis in different liver diseases or if there is always a different necroptosis initiator in each specific disease condition followed by specific downstream signaling molecules. Understanding the precise mechanism of necroptosis as well as counteracting other cell death pathways in liver diseases could provide a useful insight towards achieving extensive therapeutic significance. By targeting necroptosis and/or other parallel death pathways, a significant cell loss and thus a decrement in an organ's physiological function can be prevented. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
URI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168087/http://hdl.handle.net/20.500.11754/51548
ISSN
1007-9327; 2219-2840
DOI
10.3748/wjg.v20.i35.12526
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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