Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-03-23T06:19:54Z | - |
dc.date.available | 2018-03-23T06:19:54Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | Clinical Rheumatology, 2012, 31(12), P.1733-1739 | en_US |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs10067-012-2080-7 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51381 | - |
dc.description.abstract | The aim of this study was to summarize published results on the association between vitamin D intake and the development of rheumatoid arthritis (RA) and between serum vitamin D levels and RA activity. Evidence of a relationship between vitamin D intake and the development of RA and between serum vitamin D levels and RA activity was studied by summarizing published results using a meta-analysis approach. Three cohort studies including 215,757 participants and 874 incident cases of RA were considered in this meta-analysis, and eight studies on the association between serum vitamin D levels and RA activity involving 2,885 RA patients and 1,084 controls were included. Meta-analysis showed an association between total vitamin D intake and RA incidence (relative risk (RR) of the highest vs. the lowest group = 0.758, 95 % confidence interval (CI) 0.577-0.937, p = 0.047), without between-study heterogeneity (I (2) = 0 %, p = 0.595). Individuals in the highest group for total vitamin D intake were found to have a 24.2 % lower risk of developing RA than those in the lowest group. Subgroup meta-analysis also showed a significant association between vitamin D supplement intake and RA incidence (RR 0.764, 95 % CI 0.628-0.930, p = 0.007), without between-study heterogeneity. All studies, except for one, found that vitamin D levels are inversely associated with RA activity. One study found no correlation between vitamin D levels and disease activity among 85 RA patients, but these patients had a high incidence of vitamin D deficiency, which might have influenced the study outcome. Meta-analysis of 215,757 participants suggests that low vitamin D intake is associated with an elevated risk of RA development. Furthermore, available evidence indicates that vitamin D level is associated with RA activity. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Healthcare Technology R&D Project, Korean Ministry of Health and Welfare (A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science + Business Media | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Susceptibility | en_US |
dc.subject | Vitamin D | en_US |
dc.title | Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 31 | - |
dc.identifier.doi | 10.1007/s10067-012-2080-7 | - |
dc.relation.page | 1733-1739 | - |
dc.relation.journal | CLINICAL RHEUMATOLOGY | - |
dc.contributor.googleauthor | Song, GwanGyu | - |
dc.contributor.googleauthor | Bae, SangCheol | - |
dc.contributor.googleauthor | Lee, YoungHo | - |
dc.relation.code | 2012202038 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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