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dc.contributor.author배상철-
dc.date.accessioned2018-03-23T05:58:47Z-
dc.date.available2018-03-23T05:58:47Z-
dc.date.issued2012-12-
dc.identifier.citationMolecular Biology Reports, 2012, 39(12), P.10655-10663en_US
dc.identifier.issn0301-4851-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs11033-012-1955-7-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/51340-
dc.description.abstractThe aim of this study was to determine whether interleukin-23 receptor (IL-23R) polymorphisms confer susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-23R rs1343151, rs10489629, rs7517847, rs11209026, rs1004819, and rs2201841 polymorphisms and RA using (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 13 studies from eight articles involving 10,016 RA patients and 11,967 controls were considered in the meta-analysis. Meta-analysis identified a significant association between RA and the A allele of the rs1343151 polymorphism in the overall population (OR = 1.110, 95 % CI = 1.056-1.168, p = 4.7 x 10(-6)). Stratification by ethnicity identified a significant association between this polymorphism and RA in Europeans (OR = 1.105, 95 % CI = 1.049-1.163, p = 1.4 x 10(-5)). An association was also found between RA and the A allele carrier of the rs1343151 polymorphism in Europeans (OR = 1.135, 95 % CI = 1.058-1.217, p = 4.0 x 10(-5)). Meta-analysis revealed a significant association between RA and the A allele of the rs10489629 polymorphism in the overall population (OR = 1.079, 95 % CI = 1.029-1.131, p = 0.002) and in Europeans (OR = 1.092, 95 % CI = 1.038-1.149, p = 0.001). Meta-analyses of recessive, dominant, and additive models showed the same pattern as the meta-analysis of the A allele of the rs10489629 polymorphism, that is, a significant association with RA in Europeans. However, no association was found between the IL-23R rs7517847, rs11209026, rs1004819, and rs2201841 polymorphisms and RA susceptibility. This meta-analysis shows that the IL-23R rs1343151 and rs10489629 polymorphisms are associated with the development of RA in Europeans. These findings suggest that the IL-23R genes confer susceptibility to RA in the European population, but further study of this association is required in other ethnic groups.en_US
dc.description.sponsorshipThis study was supported by the Korean Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (Grant No. A102065).en_US
dc.language.isoenen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectInterleukin-23Ren_US
dc.subjectPolymorphismen_US
dc.subjectMeta-analysisen_US
dc.titleAssociations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysisen_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume39-
dc.identifier.doi10.1007/s11033-012-1955-7-
dc.relation.page10655-10663-
dc.relation.journalMOLECULAR BIOLOGY REPORTS-
dc.contributor.googleauthorSong, GwanGyu-
dc.contributor.googleauthorBae, SangCheol-
dc.contributor.googleauthorChoi, SungJae-
dc.contributor.googleauthorJi, JongDae-
dc.contributor.googleauthorLee, YoungHo-
dc.relation.code2012206806-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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