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dc.contributor.author구혜령-
dc.date.accessioned2018-03-23T05:27:24Z-
dc.date.available2018-03-23T05:27:24Z-
dc.date.issued2013-09-
dc.identifier.citationActa radiologica, 2013, 54(7), p.731-738en_US
dc.identifier.issn0284-1851-
dc.identifier.urihttp://journals.sagepub.com/doi/abs/10.1177/0284185113483676?journalCode=acrc-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/51276-
dc.description.abstractBackground: The level of background parenchymal enhancement around tumor is known to be associated with breast cancer risk. However, there is no study investigating predictive power of parenchymal signal enhancement ratio (SER) around tumor for ipsilateral breast tumor recurrence (IBTR).Purpose: To investigate whether the breast parenchymal SER around the tumor on preoperative dynamic contrast-enhanced magnetic resonance imaging (MRI) is associated with subsequent IBTR in breast cancer patients who had undergone breast-conserving treatment.Material and Methods: Nineteen consecutive women (mean age, 44 years; range, 34?63 years) with breast cancer who developed IBTR following breast-conserving treatment and 114 control women matched for age, as well as T and N stages were included. We compared the clinicopathologic features of the two groups including nuclear grade, histologic grade, hormonal receptor status, human epidermal growth factor receptor-2 (HER-2) status, lymphovascular invasion, negative margin width, use of adjuvant therapy, and parenchymal SER around the tumor on preoperative DCE-MRI. The SER was measured on a slice showing the largest dimension of the tumor. Multivariate conditional logistic regression analysis was used to identify independent factors associated with IBTR.Results: In univariate analysis, ER negativity (odds ratio [OR] = 4.7; P = 0.040), PR negativity (OR = 4.0; P = 0.013), HER-2 positivity (OR = 3.6; P = 0.026), and a parenchymal SER greater than 0.53 (OR = 23.3; P = 0.011) were associated with IBTR. In multivariate analysis, ER negativity (OR = 3.8; P = 0.015) and a parenchymal SER greater than 0.53 (OR = 13.2; P = 0.040) on preoperative MRI were independent factors associated with IBTR.Conclusion: In addition to ER negativity, a higher parenchymal SER on preoperative MRI was an independent factor associated with subsequent IBTR in patients with breast cancer who had undergone breast-conserving treatment.en_US
dc.language.isoenen_US
dc.publisherActa Radiologicaen_US
dc.subjectBreasten_US
dc.subjectneoplasms primaryen_US
dc.subjectMR imagingen_US
dc.titlePredicting local recurrence following breast-conserving treatment: parenchymal signal enhancement ratio (SER) around the tumor on preoperative MRIen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume54-
dc.identifier.doi10.1177/0284185113483676-
dc.relation.page731-738-
dc.relation.journalACTA RADIOLOGICA-
dc.contributor.googleauthorKim, Mi-Young-
dc.contributor.googleauthorCho, Nariya-
dc.contributor.googleauthorYun, Bo-La-
dc.contributor.googleauthorBae, Min-Sun-
dc.contributor.googleauthorChie, Eui-Kyu-
dc.contributor.googleauthorMoon, Woo-Kyung-
dc.contributor.googleauthorKoo, Hye-Ryoung-
dc.relation.code2013008671-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhuilings-
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