Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease
- Title
- Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease
- Author
- 전대원
- Keywords
- Feces; microbiology; Female; Hepatitis B; Chronic; diagnosis; therapy; Hepatitis C; Chronic; Humans; Intestine; Small; metabolism; Liver Diseases; Alcoholic; Male; Middle Aged; Permeability; Probiotics; Republic of Korea; Time Factors; Treatment Outcome
- Issue Date
- 2014-11
- Publisher
- LIPPINCOTT WILLIAMS AND WILKINS
- Citation
- European Journal of Gastroenterology and Hepatology,vol.26, no.12, p1353 - 1362p
- Abstract
- AIM:: Although numerous animal studies suggest that probiotic therapy has beneficial effects in various liver diseases, the evidence for beneficial effects in human liver disease is controversial. This study was carried out to investigate the efficacy of probiotic therapy in alleviating small intestinal bacterial overgrowth (SIBO) and permeability in chronic liver disease. METHODS:: Fifty-three patients with chronic liver disease were randomized to either probiotic therapy or placebo. Six bacterial species were used: Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Streptococcus thermophilus. After 4 weeks, changes in the composition of fecal bacteria, SIBO, intestinal permeability, and clinical symptoms were examined. RESULTS:: Three of the six probiotic species, B. lactis, L. rhamnosus, and L. acidophilus, increased in the feces of the probiotic therapy group (P
- URI
- http://ovidsp.tx.ovid.com/sp-3.28.0a/ovidweb.cgi?QS2=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://hdl.handle.net/20.500.11754/51231
- ISSN
- 0954-691X; 1473-5687
- DOI
- 10.1097/MEG.0000000000000214
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML