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Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease

Title
Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease
Author
전대원
Keywords
Feces; microbiology; Female; Hepatitis B; Chronic; diagnosis; therapy; Hepatitis C; Chronic; Humans; Intestine; Small; metabolism; Liver Diseases; Alcoholic; Male; Middle Aged; Permeability; Probiotics; Republic of Korea; Time Factors; Treatment Outcome
Issue Date
2014-11
Publisher
LIPPINCOTT WILLIAMS AND WILKINS
Citation
European Journal of Gastroenterology and Hepatology,vol.26, no.12, p1353 - 1362p
Abstract
AIM:: Although numerous animal studies suggest that probiotic therapy has beneficial effects in various liver diseases, the evidence for beneficial effects in human liver disease is controversial. This study was carried out to investigate the efficacy of probiotic therapy in alleviating small intestinal bacterial overgrowth (SIBO) and permeability in chronic liver disease. METHODS:: Fifty-three patients with chronic liver disease were randomized to either probiotic therapy or placebo. Six bacterial species were used: Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Streptococcus thermophilus. After 4 weeks, changes in the composition of fecal bacteria, SIBO, intestinal permeability, and clinical symptoms were examined. RESULTS:: Three of the six probiotic species, B. lactis, L. rhamnosus, and L. acidophilus, increased in the feces of the probiotic therapy group (P
URI
http://ovidsp.tx.ovid.com/sp-3.28.0a/ovidweb.cgi?QS2=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://hdl.handle.net/20.500.11754/51231
ISSN
0954-691X; 1473-5687
DOI
10.1097/MEG.0000000000000214
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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