104 0

Stiffness of tumours measured by shear-wave elastography correlated with subtypes of breast cancer

Title
Stiffness of tumours measured by shear-wave elastography correlated with subtypes of breast cancer
Author
구혜령
Keywords
Shear wave; Elastography; Ultrasound; Breast cancer subtype; Stiffness
Issue Date
2013-09
Publisher
Springer Science + Business Media
Citation
European radiology, 2013, 23(9), p.2450-2458
Abstract
Objective: To evaluate the correlation between stiffness values obtained by shear-wave elastography (SWE) and breast cancer subtypes. Methods: This was an institutional review board-approved retrospective study with a waiver of informed consent. The stiffness of 337 invasive breast cancers in 337 women was evaluated by SWE and mean stiffness values (kPa) and qualitative colour scores (1-5) of tumours were obtained. The results were analysed according to BI-RADS category, tumour size, grade and tumour subtype (triple-negative [TN], human epidermal growth factor receptor 2 [HER2]-positive, and oestrogen receptor [ER]-positive) using a multiple linear regression analysis. Results: The mean stiffness values and colour scores were: 146.8 kPa ± 57.0 and 4.1 ± 1.1; 165.8 kPa ± 48.5 and 4.6 ± 0.7 for TN tumours ( n = 64), 160.3 kPa ± 56.2 and 4.3 ± 1.0 for HER2-positive tumours ( n = 55) and 136.9 kPa ± 57.2 and 4.0 ± 1.1 for ER-positive tumours ( n = 218; P < 0.0001). All three breast cancers classified as BI-RADS category 3 on B-mode ultrasound were TN subtype. A multiple linear regression analysis revealed that tumour size, histological grade and tumour subtype were independent factors that influenced the stiffness values. Conclusion: High stiffness values correlated with aggressive subtypes of breast cancer. Key points: ? Shear-wave elastography is increasingly used to measure the stiffness of breast tumours. ? Triple-negative and HER2-positive tumours showed greater stiffness than ER-positive tumours.? All breast cancers classified as BI-RADS 3 on B-mode ultrasound were triple-negative subtype.? Tumour size, histological grade and subtype were independent factors influencing SWE stiffness.
URI
https://link.springer.com/article/10.1007%2Fs00330-013-2866-2http://hdl.handle.net/20.500.11754/51217
ISSN
0938-7994
DOI
10.1007/s00330-013-2866-2
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE