Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정승준 | - |
dc.date.accessioned | 2018-03-23T04:16:50Z | - |
dc.date.available | 2018-03-23T04:16:50Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | Development (Cambridge), 2012, 139(13), P.2447-2451 | en_US |
dc.identifier.issn | 0950-1991 | - |
dc.identifier.uri | http://dev.biologists.org/content/139/13/2447 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51153 | - |
dc.description.abstract | Neural stem/progenitor cell (NSC/NPC) cultures can be a source of dopamine (DA) neurons for experimental and transplantationpurposes. Nurr1, a steroid receptor transcription factor, can overcome the limitations associated with differentiation of cultured NPCsinto DA neurons. However, forced Nurr1 expression in NPC cultures generates non-neuronal and/or immature DA cells. We showhere that the Nurr1 level and period of expression crucially affect the differentiation and maturation of Nurr1-induced DA neurons.Mature DA neurons were generated by manipulating Nurr1 expression patterns to resemble those in the developing midbrain. | en_US |
dc.description.sponsorship | This work was supported by the Future-based Technology Development Program [2011-0019404]; the Medical Research Center [2011-0028261]; Basic Science Research Program [2012-0002653]; and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology [KRF-2008-355-C00018]. | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Company of Biologists Ltd | en_US |
dc.subject | Parkinson’s disease | en_US |
dc.subject | Dopamine neurons | en_US |
dc.subject | Nurr1 | en_US |
dc.subject | Neuronal maturation | en_US |
dc.subject | Doxycycline inducible expression system | en_US |
dc.title | In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1 | en_US |
dc.type | Article | en_US |
dc.relation.no | 13 | - |
dc.relation.volume | 139 | - |
dc.identifier.doi | 10.1242/dev.075978 | - |
dc.relation.page | 2447-2451 | - |
dc.relation.journal | DEVELOPMENT | - |
dc.contributor.googleauthor | Park, Chang-Hwan | - |
dc.contributor.googleauthor | Lim, Mi-Sun | - |
dc.contributor.googleauthor | Rhee, Yong-Hee | - |
dc.contributor.googleauthor | Yi, Sang-Hoon | - |
dc.contributor.googleauthor | Kim, Boe-Kyoung | - |
dc.contributor.googleauthor | Shim, Jae-Won | - |
dc.contributor.googleauthor | Kim, Yong Ho | - |
dc.contributor.googleauthor | Jung, Sung Jun | - |
dc.contributor.googleauthor | Lee, Sang-Hun | - |
dc.relation.code | 2012202530 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | eurijj | - |
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