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dc.contributor.author정승준-
dc.date.accessioned2018-03-23T01:48:48Z-
dc.date.available2018-03-23T01:48:48Z-
dc.date.issued2013-11-
dc.identifier.citationJournal of Dental Research, 92, P.948-955en_US
dc.identifier.issn0022-0345-
dc.identifier.issn1544-0591-
dc.identifier.urihttp://journals.sagepub.com/doi/abs/10.1177/0022034513501877?journalCode=jdrb-
dc.description.abstractDue, in part, to the unique structure of the tooth, dental pain is initiated via distinct mechanisms. Here we review recent advances in our understanding of inflammatory tooth pain and discuss 3 hypotheses proposed to explain dentinal hypersensitivity: The first hypothesis, supported by functional expression of temperature-sensitive transient receptor potential channels, emphasizes the direct transduction of noxious temperatures by dental primary afferent neurons. The second hypothesis, known as hydrodynamic theory, attributes dental pain to fluid movement within dentinal tubules, and we discuss several candidate cellular mechanical transducers for the detection of fluid movement. The third hypothesis focuses on the potential sensory function of odontoblasts in the detection of thermal or mechanical stimuli, and we discuss the accumulating evidence that supports their excitability. We also briefly update on a novel strategy for local nociceptive anesthesia via nociceptive transducer molecules in dental primary afferents with the potential to specifically silence pain fibers during dental treatment. Further understanding of the molecular mechanisms of dental pain would greatly enhance the development of therapeutics that target dental pain.en_US
dc.description.sponsorshipThe authors thank Dr. Alexander J. Davies for editing this article. This work was supported by the National Research Foundation of Korea (NRF) (grant 2012R1A3A2048834 to SBO; grant 2012R1A1A1042191 to GC), funded by the Korean government (MSIP). The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.subjectnociceptoren_US
dc.subjecthydrodynamic theoryen_US
dc.subjectdentinal hypersensitivityen_US
dc.subjectodontoblastsen_US
dc.subjectneurobiologyen_US
dc.subjectanesthesiaen_US
dc.titleCellular and Molecular Mechanisms of Dental Nociceptionen_US
dc.typeArticleen_US
dc.relation.volume92-
dc.identifier.doi10.1177/0022034513501877-
dc.relation.page948-955-
dc.relation.journalJOURNAL OF DENTAL RESEARCH-
dc.contributor.googleauthorChung, G.-
dc.contributor.googleauthorJung, S.J.-
dc.contributor.googleauthorOh, S.B.-
dc.relation.code2013010622-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
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