Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma
- Title
- Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma
- Author
- 이현
- Keywords
- insulin-like growth factor-I; insulin-like growth factor?binding protein-3; asthma
- Issue Date
- 2014-04
- Publisher
- American Thoracic Society
- Citation
- American Journal of Respiratory Cell and Molecular Biology. Apr 01, 2014, 50, 4, 667-677
- Abstract
- Insulin-like growth factor (IGF)-I has been recognized to play critical roles in the pathogenesis of asthma, whereas IGF-binding protein (IGFBP)-3 blocks crucial physiologic manifestations of asthma. IGF-I enhances subepithelial fibrosis, airway inflammation, airway hyperresponsiveness, and airway smooth muscle hyperplasia by interacting with various inflammatory mediators and complex signaling pathways, such as intercellular adhesion molecule-1, and the hypoxia-inducible factor/vascular endothelial growth factor axis. On the other hand, IGFBP-3 decreases airway inflammation and airway hyperresponsiveness through IGFBP-3 receptor-mediated activation of caspases, which subsequently inhibits NF-κB signaling pathway. It also inhibits the IGF-I/hypoxia-inducible factor/vascular endothelial growth factor axis via IGF-I-dependent and/or IGF-I-independent mechanisms. This Translational Review summarizes the role of IGF-I and IGFBP-3 in the context of allergic airway disease, and discusses the therapeutic potential of various strategies targeting the IGF-I and IGFBP-3 signaling pathways for the management of asthma.
- URI
- https://www.atsjournals.org/doi/abs/10.1165/rcmb.2013-0397TRhttp://hdl.handle.net/20.500.11754/50984
- ISSN
- 1044-1549
- DOI
- 10.1165/rcmb.2013-0397TR
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
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