Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오재원 | - |
dc.date.accessioned | 2018-03-22T08:33:19Z | - |
dc.date.available | 2018-03-22T08:33:19Z | - |
dc.date.issued | 2013-08 | - |
dc.identifier.citation | Annals of Allergy, Asthma & Immunology, Aug 2013, 111(2), P.112-117(6) | en_US |
dc.identifier.issn | 1081-1206 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1081120613003530 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50829 | - |
dc.description.abstract | Background: Leptin-related effects on inflammation and bronchial hyperresponsiveness (BHR) in the human airway have not been demonstrated.Objectives: To investigate the relationship between the levels of serum leptin and BHR and urinary leukotriene E-4 (LTE4) and 9 alpha,11 beta-prostaglandin F-2 (9 alpha,11 beta-PGF(2)) release after exercise challenge in asthmatic children.Methods: Eighty-six prepubertal children between 6 and 10 years old were enrolled and divided into 4 groups: 19 obese asthmatic children, 25 normal-weight asthmatic children, 21 obese nonasthmatic children, and 21 healthy controls. We measured serum leptin levels and urinary LTE4 and 9 alpha,11 beta-PGF(2) levels in children before and 30 minutes after the exercise challenge.Results: Serum leptin levels were significantly higher in obese asthmatic children compared with normal-weight asthmatic children. Significant increases in urinary levels of LTE4 and 9 alpha,11 beta-PGF(2) were observed in obese asthmatic children after the exercise challenge. Although smaller than in obese asthmatic children, significant increases in the urinary levels of LTE4 and 9 alpha,11 beta-PGF(2) were also observed in the normal-weight. Asthmatic children Logarithmic serum leptin values were significantly associated with the logarithmic maximum percentage change in forced expiratory volume in 1 second, the logarithmic urinary LTE4 change, and the logarithmic urinary 9 alpha,11 beta-PGF(2) change from baseline to after exercise in both obese and normal-weight asthmatic children.Conclusion: The serum levels of leptin were significantly associated with BHR and urinary LTE4 and 9 alpha,11 beta-PGF(2) release induced by exercise challenge in asthmatic children. (c) 2013 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | We thank our pediatric patients and their parents for generous donation of study samples, Mr Soon-Ho Koo for technical assistance, and Professor Young-Gwan Im and Mr Han-Sang Baek for data management. We also thank Aerocrine for their kind support of the NIOX MINO for exhaled nitric oxide measurement. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science INC | en_US |
dc.subject | BODY-MASS INDEX | en_US |
dc.subject | ALLERGIC AIRWAY RESPONSES | en_US |
dc.subject | INDUCED BRONCHOCONSTRICTION | en_US |
dc.subject | CELL ACTIVATION | en_US |
dc.subject | INDUCED ASTHMA | en_US |
dc.subject | CHILDREN | en_US |
dc.subject | INFLAMMATION | en_US |
dc.subject | MICE | en_US |
dc.subject | HYPERRESPONSIVENESS | en_US |
dc.subject | OVERWEIGHT | en_US |
dc.title | Leptin and urinary leukotriene E-4 and 9 alpha,11 beta-prostaglandin F-2 release after exercise challenge | en_US |
dc.type | Article | en_US |
dc.relation.volume | 111 | - |
dc.identifier.doi | 10.1016/j.anai.2013.05.019 | - |
dc.relation.page | 112-117 | - |
dc.relation.journal | ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | - |
dc.contributor.googleauthor | Baek, Hey-Sung | - |
dc.contributor.googleauthor | Choi, Jae-Hyung | - |
dc.contributor.googleauthor | Oh, Jae-Won | - |
dc.contributor.googleauthor | Lee, Ha-Baik | - |
dc.relation.code | 2013008867 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jaewonoh | - |
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