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Added Value of Shear-Wave Elastography for Evaluation of Breast Masses Detected with Screening US Imaging

Title
Added Value of Shear-Wave Elastography for Evaluation of Breast Masses Detected with Screening US Imaging
Author
구혜령
Keywords
ULTRASOUND ELASTOGRAPHY; QUALITATIVE ASSESSMENT; CLINICAL-APPLICATION; INITIAL-EXPERIENCE; DENSE BREASTS; BENIGN; CANCER; LESIONS; MAMMOGRAPHY; PERFORMANCE
Issue Date
2014-10
Publisher
RADIOLOGICAL SOCIETY OF NORTH AMERICA
Citation
RADIOLOGY; OCT 2014, 273 1, p61-p69, 9p.
Abstract
Purpose: To evaluate the additional value of shear-wave elastography (SWE) to B-mode ultrasonography (US) and to determine an appropriate guideline for the combined assessment of screening US-detected breast masses. Materials and Methods: This study was conducted with institutional review board approval, and written informed consent was obtained. From March 2010 to February 2012, B-mode US and SWE were performed in 159 US-detected breast masses before biopsy. For each lesion, Breast Imaging Reporting and Data System (BI-RADS) category on B-mode US images and the maximum stiffness color and elasticity values on SWE images were assessed. A guideline for adding SWE data to B-mode US was developed with the retrospective cohort to improve diagnostic performance in sensitivity and specificity and was validated in a distinct prospective cohort of 207 women prior to biopsy. Results: Twenty-one of 159 masses in the development cohort and 12 of 207 breast masses in the validation cohort were malignant. In the development cohort, when BI-RADS category 4a masses showing a dark blue color or a maximum elasticity value of 30 kPa or less on SWE images were downgraded to category 3, specificity increased from 9.4% (13 of 138) to 59.4% (82 of 138) and 57.2% (79 of 138) (P < .001), respectively, without loss in sensitivity (100% [21 of 21]). In the validation cohort, specificity increased from 17.4% (34 of 195) to 62.1% (121 of 195) and 53.3% (104 of 195) (P < .001) respectively, without loss in sensitivity (91.7% [11 of 12]). Conclusion: The addition of SWE to B-mode US improved diagnostic performance with increased specificity for screening US-detected breast masses. BI-RADS category 4a masses detected at US screening that showed a dark blue color or a maximum elasticity value of 30 kPa or less on SWE images can be safely followed up instead of performing biopsy. (C) RSNA, 2014
URI
https://pubs.rsna.org/doi/abs/10.1148/radiol.14132443http://hdl.handle.net/20.500.11754/50825
ISSN
0033-8419; 1527-1315
DOI
10.1148/radiol.14132443
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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