Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고인송 | - |
dc.date.accessioned | 2018-03-22T08:10:59Z | - |
dc.date.available | 2018-03-22T08:10:59Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | Allergy, asthma & immunology research,v.6,no.2 2014년, pp.142 - 148 | en_US |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2014.6.2.142 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50783 | - |
dc.description.abstract | Purpose: Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma.Activating transcription factor 6β (ATF6B) is known to regulate ATFα-mediated ER stress response. The aim of this study is to investigate the associationsof ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation.Methods: Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patientsand 96 aspirin-tolerant asthma (ATA) as controls. Results: Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; correctedP=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation,whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD. Conclusions: Although further functional and replicationstudies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure inadult asthmatics. | en_US |
dc.description.sponsorship | This work was supported by a grant from the Korea Health 21 R&D Project (A010249); a grant from the Korea Science and Engineering Foundation (KOSEF), funded by the Korean government (MEST) (2009-0080157); a grant from the Priority Research Centers Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2012-0006690); and a Sogang University Research Grant of 2012 (SRF-201214006.01). | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한천식알레르기학회 | en_US |
dc.subject | ATF6B | en_US |
dc.subject | aspirin exacerbated respiratory disease (AERD) | en_US |
dc.subject | single nucleotide polymorphism (SNP) | en_US |
dc.subject | haplotype | en_US |
dc.title | Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics | en_US |
dc.type | Article | en_US |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.4168/aair.2014.6.2.142 | - |
dc.relation.page | 142-148 | - |
dc.relation.journal | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.contributor.googleauthor | Park, Tae-Joon | - |
dc.contributor.googleauthor | Kim, Jeong-Hyun | - |
dc.contributor.googleauthor | Pasaje, Charisse F. | - |
dc.contributor.googleauthor | Park, Byung-Lae | - |
dc.contributor.googleauthor | Bae, Joon-Seol | - |
dc.contributor.googleauthor | Uh, Soo-Taek | - |
dc.contributor.googleauthor | Kim, Yong-Hoon | - |
dc.contributor.googleauthor | Kim, Mi-Kyeong | - |
dc.contributor.googleauthor | Choi, Inseon S. | - |
dc.contributor.googleauthor | Koh, In-Song | - |
dc.relation.code | 2014024562 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | insong | - |
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