Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진웅 | - |
dc.date.accessioned | 2018-03-22T07:17:25Z | - |
dc.date.available | 2018-03-22T07:17:25Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL OPTICS, 권: 19, 호: 10 | en_US |
dc.identifier.issn | 1083-3668 | - |
dc.identifier.issn | 1560-2281 | - |
dc.identifier.uri | http://www.spiedigitallibrary.org/journals/Journal_of_Biomedical_Optics/volume-19/issue-10/106006/Evaluation-of-transdermal-delivery-of-nanoemulsions-in-ex-vivo-porcine/10.1117/1.JBO.19.10.106006.full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50688 | - |
dc.description.abstract | This study experimentally evaluates the self-targeting ability of asiaticoside-loaded nanoemulsions compared with nontargeted nanoemulsions in ex vivo experiments with porcine skin samples. Homebuilt two-photon and confocal laser-scanning microscopes were employed to noninvasively examine the transdermal delivery of two distinct nanoemulsions. Prior to the application of nanoemulsions, we noninvasively observed the morphology of porcine skin using two-photon microscopy. We have successfully visualized the distributions of the targeted and nontargeted nanoemulsions absorbed into the porcine skin samples. Asiaticoside-loaded nanoemulsions showed an improved ex vivo transdermal delivery through the stratum corneum compared with nonloaded nanoemulsions. As a secondary measure, nanoemulsions-applied samples were sliced in the depth direction with a surgical knife in order to obtain the complete depth-direction distribution profile of Nile red fluorescence. XZ images demonstrated that asiaticoside-loaded nanoemulsion penetrated deeper into the skin compared with nontargeted nanoemulsions. The basal layer boundary is clearly visible in the case of the asiaticoside-loaded skin sample. These results reaffirm the feasibility of using self-targeting ligands to improve permeation through the skin barrier for cosmetics and topical drug applications. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) | en_US |
dc.description.sponsorship | This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. HN12C0063) and by the National Research Foundation of Korea grant funded by the Korea government (MSIP) (No. 2008-0061891). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS | en_US |
dc.subject | transdermal delivery | en_US |
dc.subject | two-photon microscopy | en_US |
dc.subject | two-photon microscopy | en_US |
dc.subject | confocal laser scanning microscopy | en_US |
dc.title | Evaluation of transdermal delivery of nanoemulsions in ex vivo porcine skin using two-photon microscopy and confocal laser-scanning microscopy | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1117/1.JBO.19.10.106006 | - |
dc.identifier.doi | 10.1117/1.JBO.19.10.106006 | - |
dc.relation.page | 106006-106006 | - |
dc.relation.journal | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.contributor.googleauthor | ChoiChoi, S S | - |
dc.contributor.googleauthor | KimKim, J.W J.W | - |
dc.contributor.googleauthor | LeeLee, Y.J Y.J | - |
dc.contributor.googleauthor | DelmasDelmas, T T | - |
dc.contributor.googleauthor | KimKim, C C | - |
dc.contributor.googleauthor | ParkPark, S S | - |
dc.contributor.googleauthor | LeeLee, H H | - |
dc.relation.code | 2014032529 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | kjwoong | - |
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