Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 전재범 | - |
dc.date.accessioned | 2018-03-22T07:05:25Z | - |
dc.date.available | 2018-03-22T07:05:25Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.citation | Annals of the rheumatic diseases : the official journal, 2013, 72(3), pp.852 - 852 | en_US |
dc.identifier.issn | 0003-4967 | - |
dc.identifier.uri | http://ard.bmj.com/content/72/Suppl_3/A851.4 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50662 | - |
dc.description.abstract | Background Treatment of rheumatoid arthritis (RA) patients with hepatitis B carries risk for reactivation of hepatitis B and drug-related hepatotoxicity.Objectives We investigated the impact of treatment for RA in patients with hepatitis B.Methods Patients enrolled in KORONA (Korean Observational Study Network for Arthritis) with 1-year follow up assessment with data on hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (HBcAb) status were included in the analysis. Patient characteristics (age, sex, disease duration, delay in diagnosis, alcohol intake), disease outcome measures (DAS28, fatigue, sleep, HAQ, EQ-5D, radiographic damage, surgery), medications, and adverse events were assessed. Multiple logistic regression was used to analyze the predicting factors for liver function abnormalities.Results : A total of 871 patients were assessed. The number of HBsAg-positive and HBcAb-positive patients were 48 (5.5%) and 372 (42.7%), respectively. HBcAb-positive groups were significantly older (56.3 ± 10.8 vs 52.5 ± 9.0 in HBsAg-positive group and 51.3 ± 13.3 in negative group, p<0.01) and had longer disease duration (8.4 ± 7.7 vs 7.7 ± 6.0 in HBsAg-positive group and 7.8 ± 7.2 in negative-group, p=0.46). There was no significant difference in disease outcome measures between the groups, except for significantly increased radiographic damage in HBcAb group (79.6% vs 70.8% in HBsAg-positive group and 72.5% in negative group, p=0.048). Methotrexate and biologics use were significantly lower in HBsAg-positive group, while hydroxychloroquine, sulfasalazine, tacrolimus, and steroids use were significantly higher. HBsAg-positive group had significantly more adverse events (52.1%) compared to HBcAb-positive group (29.3%) and negative group (32.8%). HBsAg-positivity and HBcAb-positivity was not associated with significant increase in liver function abnormalities in the study population in multiple logistic regression analysis (OR (95%CI), 2.2 (0.7-7.4) and 0.8 (0.4-1.7), respectively).Conclusions HBsAg-positive patients were more frequently treated with steroids and less with methotrexate, but there was no significant difference in disease outcome. HBsAg-positive patients had more adverse events, but it did not show significant association with developing liver function abnormality. | en_US |
dc.description.sponsorship | This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | BMJ PUBLISHING GROUP | en_US |
dc.title | TREATMENT AND OUTCOMES OF RHEUMATOID ARTHRITIS PATIENTS WITH HEPATITIS B | en_US |
dc.type | Article | en_US |
dc.relation.volume | 72 | - |
dc.identifier.doi | 10.1136/annrheumdis-2013-eular.2536 | - |
dc.relation.page | 851-852 | - |
dc.relation.journal | ANNALS OF THE RHEUMATIC DISEASES | - |
dc.contributor.googleauthor | Choi, C. -B. . | - |
dc.contributor.googleauthor | Sung, Y. -K | - |
dc.contributor.googleauthor | Cho, S. -K. | - |
dc.contributor.googleauthor | Yoo, D. -H. | - |
dc.contributor.googleauthor | Lee, S. -S. | - |
dc.contributor.googleauthor | Lee, J. | - |
dc.contributor.googleauthor | Kim, J. | - |
dc.contributor.googleauthor | Lee, H. -S. | - |
dc.contributor.googleauthor | Kim, T. -H. | - |
dc.contributor.googleauthor | Bang, S. -Y | - |
dc.relation.code | 2013008904 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | junjb | - |
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