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Association between functional Fc receptor-like 3 (FCRL3)-169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians: A meta-analysis

Title
Association between functional Fc receptor-like 3 (FCRL3)-169 C/T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians: A meta-analysis
Other Titles
T polymorphism and susceptibility to seropositive rheumatoid arthritis in Asians: A meta-analysis
Author
배상철
Keywords
SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENE POLYMORPHISMS; FCRL3 GENE; POPULATION; CAUCASIANS; FAMILY
Issue Date
2013-09
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Human immunology, 2013, 74(9), p.1206-1213
Abstract
Objective: The aim of this study was to determine whether the functional Fc receptor like-3 (FCRL3) ?169 C/T polymorphism confers susceptibility to rheumatoid arthritis (RA).Methods: A meta-analysis was conducted on the associations between the FCRL3 ?169 C/T polymorphism and RA.Results: A total of 17 comparison studies including 11,170 patients and 11,142 controls were considered in the meta-analysis. The meta-analysis showed no association between RA and the FCRL3 ?169 C allele in study subjects (OR = 1.046, 95% CI = 0.997?1.098, p = 0.068). Stratification by ethnicity indicated an association between the FCRL3 ?169 C allele and RA in Asians (OR = 1.101, 95% CI = 1.035?1.174, p = 0.002), but not in Europeans. Stratification of patients according to the presence of rheumatoid factor (RF) revealed a different significant association between the C allele and RA in RF-positive and RF-negative RA patients. Stratification by ethnicity indicated an association between the FCRL3 ?169 C allele and RF-positive RA in Asians (OR = 1.093, 95% CI = 1.004?1.189, p = 0.040), but not in Europeans.Conclusions: This meta-analysis demonstrates that the FCRL3 ?169 C/T polymorphism may confer susceptibility to seropositive RA in Asians.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0198885913001596http://hdl.handle.net/20.500.11754/50643
ISSN
0198-8859
DOI
10.1016/j.humimm.2013.05.018
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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