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dc.contributor.author황승용-
dc.date.accessioned2018-03-22T06:53:44Z-
dc.date.available2018-03-22T06:53:44Z-
dc.date.issued2014-03-
dc.identifier.citationInternational journal of oncology,v.44,no.3 2014년, pp.970 - 976en_US
dc.identifier.issn1019-6439-
dc.identifier.issn1791-2423-
dc.identifier.urihttps://www.spandidos-publications.com/ijo/44/3/970-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/50631-
dc.description.abstractAll-trans retinoic acid (ATRA) is one of the most useful drugs in the treatment for acute promyelocytic leukemia (APL), but its adverse effects, which include drug resistance and hypercalcemia are obstacles to achieving complete remission. Our previous study showed that some sesquiterpene lactones (STLs), i.e., helenalin (HE) and parthenolide (PA) but not sclareolide (SC), enhance ATRA-induced differentiation of HL-60 APL cells with no unexpected effects, but the precise mechanism on underlying this synergism is not yet fully understood. In this study, we investigated the distinctive transcriptional profile of cells treated with effective STL compounds, which were identified by comparing the profile with that of cells treated with SC. Genome-wide approaches using cDNA microarrays showed that co-treatment with the differentiation-enhancing STLs HE and PA maximized the transcriptional variation regulated by the suboptimal concentration of ATRA in HL-60 cells. Of the genes of interest, asparagine synthetase was remarkably downregulated by ATRA co-treated with either HE or PA, but not with SC. In an additional analysis for the role of asparagine synthetase, ATRA-mediated HL-60 cell differentiation was enhanced when asparagine in the culture media was depleted by an addition of L-asparaginase, indicating that downregulation of asparagine synthetase gene expression may be involved in the enhanced cell differentiation by STL compounds. These results provide useful insight into differentiation-inducing therapy in the treatment of leukemia.en_US
dc.description.sponsorshipThis study was supported, by the grant of the National Project for Personalized Genomic Medicine, Ministry for Health and Welfare (no. A111218-GM06), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (no. 2005-0049410), and a Korea University grant.en_US
dc.language.isoenen_US
dc.publisherSpandidos Publicationsen_US
dc.subjectAll-trans retinoic aciden_US
dc.subjectacute promyelocytic leukemiaen_US
dc.subjectasparagine synthetaseen_US
dc.subjectdifferentiationen_US
dc.subjectsesquiterpene lactoneen_US
dc.titleAnalysis of gene profiles involved in the enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by sesquiterpene lactones identifies asparagine synthetase as a novel target for differentiation-inducing therapyen_US
dc.typeArticleen_US
dc.relation.volume44-
dc.identifier.doi10.3892/ijo.2013.2241-
dc.relation.page970-976-
dc.relation.journalINTERNATIONAL JOURNAL OF ONCOLOGY-
dc.contributor.googleauthorSong, Ju-Han-
dc.contributor.googleauthorKim, Seung-Hyun-
dc.contributor.googleauthorCho, Kyung-Min-
dc.contributor.googleauthorHwang, Seung-Yong-
dc.contributor.googleauthorKim, Hyeoung-Joon-
dc.contributor.googleauthorKim, Tae-Sung-
dc.relation.code2014031679-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidsyhwang-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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