Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주한 | - |
dc.date.accessioned | 2018-03-22T06:24:09Z | - |
dc.date.available | 2018-03-22T06:24:09Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | The Canadian journal of neurological sciences, 2013, 40(5), p.657-662 | en_US |
dc.identifier.issn | 0317-1671 | - |
dc.identifier.issn | 2057-0155 | - |
dc.identifier.uri | https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50584 | - |
dc.description.abstract | Background: Visual hallucination (VH) is a common psychotic symptom in patients with Parkinson’s disease (PD) andmay be a significant predictor of cognitive impairment (CI) in such patients.Objective: This study aimed to investigate the pattern of glucose metabolism of VH and the relationship between VH and CI in PD. Methods: We studied 28 PD patients, including 15 with VH(PD-VH) and 13 without VH (PD-NVH). Of the 15 PD-VH patients, 8 patients had cognitive impairment (PD-VHCI) whereas 7 did not (PD-VHNCI). All patients underwent [18F] fluorodeoxyglucose positron emission tomography ([18F] FDG PET) followed by statistical parametric mapping (SPM) analyses. Results: Compared to the patients with PDNVH, PD-VHNCI patients showed glucose hypometabolism in the inferior and middle temporal cortices, fusiform gyri, and frontal areas, suggesting the involvement of the ventral visual pathway. Compared to the patients with PDNVH, PD-VHCI patients showed glucose hypometabolism in the temporoparietalassociation cortices with scattered frontal areas. Conclusion: Dysfunction of ventral visual pathway involving the temporal lobe may play a key role in VH development in PD patients. The evolving distribution from the ventral visual pathway to more extensive posterior cortices in PD-VHCI patients suggests that VH may be a prodromal symptom occurring prior to CI in PD patients. | en_US |
dc.description.sponsorship | This study was supported by a grant (2010-0416) from the Asan Institute for Life Sciences, Seoul, Korea. This work was supported by the 2012 Inje University Research Grant. | en_US |
dc.language.iso | en | en_US |
dc.publisher | CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | en_US |
dc.subject | amantadine | en_US |
dc.subject | levodopa | en_US |
dc.subject | pramipexole | en_US |
dc.subject | quetiapine | en_US |
dc.subject | ropinirole | en_US |
dc.subject | selegiline | en_US |
dc.title | Visual Hallucinations and Cognitive Impairment in Parkinson's Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 40 | - |
dc.identifier.doi | 10.1017/S0317167100014888 | - |
dc.relation.page | 657-662 | - |
dc.relation.journal | CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | - |
dc.contributor.googleauthor | Park, Hee-Kyung | - |
dc.contributor.googleauthor | Kim, Jae-Seung | - |
dc.contributor.googleauthor | Im, Ki-Chun | - |
dc.contributor.googleauthor | Kim, Mi-Jung | - |
dc.contributor.googleauthor | Lee, Jae-Hong | - |
dc.contributor.googleauthor | Lee, Myoung C. | - |
dc.contributor.googleauthor | Chung, Sun-Ju | - |
dc.contributor.googleauthor | Kim, Ju-han | - |
dc.relation.code | 2013009286 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimjuhan | - |
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