EBV-associated T and NK cell lymphoproliferative disorders: consensus report of the 4th Asian Hematopathology Workshop
- Title
- EBV-associated T and NK cell lymphoproliferative disorders: consensus report of the 4th Asian Hematopathology Workshop
- Author
- 오영하
- Keywords
- Chronic active infection; EBV; Hemophagocytosis; Hydroa vacciniforme; Lymphoproliferative disease
- Issue Date
- 2012-11
- Publisher
- Springer
- Citation
- Journal of Hematopathology, Dec,2012, 5(4), P.319-324, 6P.
- Abstract
- T and NK cell proliferative diseases associated with acute and chronic Epstein?Barr virus (EBV) infection are uncommon and raise several clinical issues regarding diagnostic criteria and terminology. This is a summary report of the consensus meeting held in the 4th Asian Hematopathology Workshop. The umbrella term “EBV-positive T/NK lymphoproliferative disease in childhood-type” covers the entire spectrum of EBV-associated lesions in childhood, ranging from reactive to neoplastic processes. Systemic T/NK cell lymphoproliferative disease (LPD) of childhood type is defined as a fulminant disease associated with the proliferation of polyclonal, oligoclonal, or monoclonal T or NK cells and includes aggressive NK cell-associated leukemia in children. Chronic active EBV disease-type T/NK cell LPD is divided into three groups?polymorphic/polyclonal, polymorphic/monoclonal, and monomorphic/monoclonal?based on the histology and clonality of T or NK cells. A monoclonal EBV-positive T/NK cell type of proliferation with the clinical features of chronic active EBV disease rather than the fulminant course of systemic EBV-positive T/NK cell LPD of childhood is considered “chronic active EBV disease-type T/NK cell LPD”. Hydroa vacciniforme (HV)-like T cell LPD is defined as a spectrum of EBV-infected T cell proliferative diseases with homing to the skin and is further classified into a classic type, a severe type, and malignant lymphoma. Criteria to define each category of HV-like T cell LPD remain to be clarified.
- URI
- https://link.springer.com/article/10.1007%2Fs12308-012-0169-1http://hdl.handle.net/20.500.11754/50207
- ISSN
- 1865-5785
- DOI
- 10.1007/s12308-012-0169-1
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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