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dc.contributor.author정민성-
dc.date.accessioned2018-03-21T07:11:49Z-
dc.date.available2018-03-21T07:11:49Z-
dc.date.issued2013-08-
dc.identifier.citationJOURNAL OF CLINICAL PATHOLOGY , 2013, 66(8), p.681-686en_US
dc.identifier.issn0021-9746-
dc.identifier.urihttp://synapse.koreamed.org/DOIx.php?id=10.4048/jbc.2015.18.1.1-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/50115-
dc.description.abstractAims Cell adhesion molecule 4 (CADM4) is a novel tumour suppressor involved in cell adhesion. Loss or decreased expression of CADM4 has been associated with the development and progression of some cancers. The purpose of this study was to investigate the clinicopathological significance of CADM4 expression in breast cancer. Methods We constructed tissue microarrays to evaluate the immunohistochemical expression of CADM4 in 256 cases of invasive ductal carcinoma (IDC) and 45 cases of ductal carcinoma in situ (DCIS). Results CADM4 was expressed in 37 (82.2%) DCIS cases, and in 173 (67.6%) IDC cases. CADM4 expression was higher in DCIS than in IDC (p=0.049). Loss or decrease of CADM4 expression was significantly correlated with higher histological grade (p=0.020), absence of oestrogen receptors (p<0.001), absence of progesterone receptors (p=0.024), and overexpression of c-erbB-2 (p=0.018). In univariable and multivariable Cox regression analyses of all 256 IDC cases, CADM4 expression was not significantly associated with overall and disease-free survival. However, it showed a significant positive association with longer disease-free survival in 187 stages I and II IDC cases (p=0.039, log-rank test). Conclusions Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. CADM4 can be used as a novel marker predicting risk of recurrence and disease outcomes in stages I and II IDCen_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2012-MC).en_US
dc.publisherBRITISH MEDICAL ASSOCen_US
dc.subjectBreast Neoplasms,en_US
dc.subjectmetabolismen_US
dc.subjectpathologyen_US
dc.subjectCarcinomaen_US
dc.subjectDuctalen_US
dc.subjectBreasten_US
dc.subjectCarcinomaen_US
dc.subjectIntraductalen_US
dc.subjectNoninfiltratingen_US
dc.subjectDown-Regulationen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectKaplan-Meier Estimateen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectReceptoren_US
dc.subjectErbB-2en_US
dc.subjectReceptorsen_US
dc.subjectEstrogenen_US
dc.subjectReceptorsen_US
dc.subjectProgesteroneen_US
dc.titleClinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breasten_US
dc.typeArticleen_US
dc.identifier.doi10.1136/jclinpath-2012-201405-
dc.relation.journalJOURNAL OF CLINICAL PATHOLOGY-
dc.contributor.googleauthorJang, S.M.-
dc.contributor.googleauthorSim, J.-
dc.contributor.googleauthorHan, H.-
dc.contributor.googleauthorAhn, H.I.-
dc.contributor.googleauthorKim, H.-
dc.contributor.googleauthorYi, K.-
dc.contributor.googleauthorJun, Y.J.-
dc.contributor.googleauthorRehman, A.-
dc.contributor.googleauthorChung, M.S.-
dc.contributor.googleauthorJang, K.-
dc.relation.code2013010574-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidbovie-


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