Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-03-21T06:59:42Z | - |
dc.date.available | 2018-03-21T06:59:42Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v. 75, NO 3, Page. 322-329 | en_US |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.issn | 1435-1250 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00393-015-1581-6 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50097 | - |
dc.description.abstract | Objective. The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA). Methods. Meta-analyses were conducted on the associations between the VDR FokI, BsmI, and TaqI polymorphisms and RA. Results. A total of seven studies were considered in the meta-analysis, involving a total of 923 patients and 912 controls. Meta-analysis of the VDR FokI polymorphism showed no association between RA and the F allele in the entire studied cohort (odds ratio, OR = 1.1740, 95 % confidence interval, CI = 0.994-1.387, p = 0.059). However, stratification by ethnicity revealed a significant association between the F allele and RA in Europeans (OR = 1.402, 95 % CI = 1.126-1.746, p = 0.003). Furthermore, an association was found between RA and the VDR FokI polymorphism using both the dominant model and homozygote contrast. Meta-analysis revealed no association between RA and the VDR BsmI B and TaqI T polymorphisms in Europeans (OR for the B allele = 1.065, 95 % CI = 0.911-1.245, p = 0.427; OR for the T allele = 1.065, 95 % CI = 0.834-1.361, p = 0.613). Conclusion. This meta-analysis suggests that the VDR FokI polymorphism is associated with susceptibility to RA in European populations. | en_US |
dc.description.sponsorship | This study was supported in part by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | Immune system | en_US |
dc.subject | Autoimmune diseases | en_US |
dc.subject | Hormone receptors, nuclear | en_US |
dc.subject | MEDLINE | en_US |
dc.subject | Linkage disequilibrium | en_US |
dc.title | Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis A meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 75 | - |
dc.identifier.doi | 10.1007/s00393-015-1581-6 | - |
dc.relation.page | 322-329 | - |
dc.relation.journal | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.contributor.googleauthor | Song, G. G. | - |
dc.contributor.googleauthor | Bae, S. -C. | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.relation.code | 2016001294 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
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