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Association between the functional MHC2TA-168 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis

Title
Association between the functional MHC2TA-168 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis
Author
배상철
Keywords
Meta-analysis; MHC2TA; Polymorphism; Rheumatoid arthritis
Issue Date
2016-04
Publisher
SPRINGER LONDON LTD
Citation
CLINICAL RHEUMATOLOGY, v. 35, NO 4, Page. 901-909
Abstract
The aim of this study was to determine whether the functional major histocompatibility complex II transactivator (MHC2TA) -168 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted to estimate the association between the MHC2TA-168 A/G polymorphism and RA. A total of 15 comparative studies, which included 14,158 patients and 13,642 controls, were included in the meta-analysis. Based on the meta-analysis, there was no association between RA and the MHC2TA -168 G allele in the study subjects (OR = 1.046, 95 % CI = 0.987-1.108, p = 0.130) or Caucasians (OR = 1.027, 95 % CI = 0.986-1.070, p = 0.193). However, the country-specific meta-analysis revealed an association between the MHC2TA -168 G allele and RA in the Swedish population (OR = 1.131, 95 % CI = 1.023-1.250, p = 0.016). A direct comparison between rheumatoid factor (RF)-positive and RF-negative patients revealed that the frequency of the G allele was significantly lower in RF-positive patients (OR = 0.783, 95 % CI = 0.628-0.975, p = 0.029) than in RF-negative patients. This meta-analysis demonstrated that the MHC2TA -168 A/G polymorphism is not associated with susceptibility to RA in Caucasians.
URI
https://link.springer.com/article/10.1007%2Fs10067-015-3089-5http://hdl.handle.net/20.500.11754/50088
ISSN
0770-3198; 1434-9949
DOI
10.1007/s10067-015-3089-5
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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