Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy
- Title
- Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy
- Author
- 주재범
- Keywords
- NEAR-INFRARED ABSORBENCY
- Issue Date
- 2014-05
- Publisher
- WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
- Citation
- PHOTOCHEMISTRY AND PHOTOBIOLOGY, 권: 90, 호: 3, 페이지: 659-666
- Abstract
- Gold nanorod-attached PEGylated graphene-oxide (AuNR-PEG-GO) nanocomposites were tested for a photothermal platform both in vitro and in vivo. Cytotoxicity of AuNR was reduced after encapsulation with PEG-GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB-eliminated AuNR-PEG-GO nanocomposites was examined using dark-field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR-PEG-GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe-lamp light (60Wcm(-2)) for 5min after treatment with the AuNR-PEG-GO nanocomposites for 24h. Cell viability significantly decreased by ~40% when the AuNR-PEG-GO-encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR-PEG-GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HCl-treated AuNR-PEG-GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.
- URI
- http://onlinelibrary.wiley.com/doi/10.1111/php.12212/abstracthttp://hdl.handle.net/20.500.11754/49826
- ISSN
- 0031-8655; 1751-1097
- DOI
- 10.1111/php.12212
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > ETC
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