Dose-related effect of urinary cotinine levels on pulmonary function among Korean women.
- Title
- Dose-related effect of urinary cotinine levels on pulmonary function among Korean women.
- Author
- 장태원
- Keywords
- biomarker; spirometry; cotinine; smoking; KNHANES
- Issue Date
- 2014-05
- Publisher
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D), 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
- Citation
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 권: 18, 호: 5, 페이지: 622-627
- Abstract
- SETTING: Country-wide general population in South Korea. BACKGROUND: The dose-response relationship between smoking and pulmonary function in women may have been significantly over-estimated by studies that employed a self-reporting questionnaire. OBJECTIVE: To evaluate whether this relationship was still observed among Korean women when smoking levels were determined by urinary cotinine measurements. DESIGN: A total of 4584 Korean women from the spirometry data set of the Korean National Health and Nutrition Examination Surveys IV and V (2008-2010) were included. Analysis of covariance was performed to estimate the dose-related effect of urinary cotinine levels on pulmonary function after adjusting for covariates in this country-wide cross-sectional study. RESULTS: Compared to urinary cotinine levels (cut-off 50 ng/ml), the false-positive rate of self-reported smoking was 53.2%. After the smokers were divided into deciles, the regression coefficients for percentage forced expiratory volume in 1 second (FEV1%) and percentage forced expiratory volume/forced volume capacity (FEV1/FVC) ratio (FEV1/FVC%) were -0.2903 and -0.2680 (%/decile), respectively (both P < 0.001). CONCLUSION: It is necessary to use objective methods when determining the smoking status of Korean women. Even after reducing information bias, smoking affected pulmonary function in a dose-dependent manner.
- URI
- http://www.ingentaconnect.com/content/iuatld/ijtld/2014/00000018/00000005/art00022;jsessionid=2l391mbuc4vd3.x-ic-live-01#http://hdl.handle.net/20.500.11754/49678
- ISSN
- 1027-3719; 1815-7920
- DOI
- 10.5588/ijtld.13.0677
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
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