Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최정혜 | - |
dc.date.accessioned | 2018-03-20T02:39:48Z | - |
dc.date.available | 2018-03-20T02:39:48Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | Leukemia Research July 2014, 38, 7, 730-736 | en_US |
dc.identifier.issn | 0145-2126 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0145212614000058 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/49390 | - |
dc.description.abstract | Total body irradiation (TBI) has traditionally been used in the conditioning regimen for allogenetic hematopoietic stem cell transplantation (alloHCT) from an unrelated donor (u-HCT). However, patients are increasingly receiving a fludarabine-based conditioning regimen without TBI, as it seemed less toxic than TBI. We need to know the clinical results of non-TBI u-HCT treatments. We retrospectively investigated the clinical outcomes of allogenetic hematopoietic cell transplantation (alloHCT) from an unrelated donor without TBI (non-TBI u-HCT) and compared the clinical outcomes of fludarabine-based (FLU group) and cyclophosphamide-ATG (Cy-ATG group) conditioning regimens. Sixty-one patients received the non-TBI conditioning regimen for u-HCT (32 in the FLU group and 29 in the Cy-ATG group). The cumulative incidence of neutrophil engraftment at 30 days, platelet>20K/μL at 30 days, acute graft-versus host disease (aGvHD) at 100 days, and chronic GvHD (cGvHD) at 2 years were 87.01%, 65.57%, 35.20%, and 26.64%, respectively. However, transplantation outcomes and overall survival rates did not differ between the FLU and Cy-ATG groups. Only infused CD34+ cells >3×106kg?1 was identified as a favorable factor for survival in the multivariate analysis. In conclusion, non-TBI u-HCT was feasible and there was no difference between the FLU and Cy-ATG groups in terms of transplantation outcomes. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V | en_US |
dc.subject | Unrelated dono | en_US |
dc.subject | rTotal body irradiation | en_US |
dc.subject | Aplastic anemia | en_US |
dc.subject | Allogeneic hematopoietic stem cell transplantation | en_US |
dc.subject | Fludarabine | en_US |
dc.title | Allogeneic hematopoietic cell transplantation without total body irradiation from unrelated donor in adult patients with idiopathic aplastic anemia: Fludarabine versus cyclophosphamide-ATG | en_US |
dc.type | Article | en_US |
dc.relation.volume | 38 | - |
dc.identifier.doi | 10.1016/j.leukres.2014.01.002 | - |
dc.relation.page | 730-736 | - |
dc.relation.journal | LEUKEMIA RESEARCH | - |
dc.contributor.googleauthor | Kim, Hawk | - |
dc.contributor.googleauthor | Lee, Kyoo-Hyung | - |
dc.contributor.googleauthor | Kim, Inho | - |
dc.contributor.googleauthor | Sohn, Sang Kyun | - |
dc.contributor.googleauthor | Jung, Chul Won | - |
dc.contributor.googleauthor | Joo, Young Don | - |
dc.contributor.googleauthor | Kim, Sung-Hyun | - |
dc.contributor.googleauthor | Kim, Byung Soo | - |
dc.contributor.googleauthor | Choi, Jung Hye | - |
dc.contributor.googleauthor | Kwak, Jae-Yong | - |
dc.relation.code | 2014035411 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jhcmd | - |
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