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Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization

Title
Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization
Author
채필석
Keywords
amphiphiles; membrane proteins; molecular design; protein solubilization; protein stabilization
Issue Date
2014-02
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMISTRY-AN ASIAN JOURNAL, 9, 2, p632-p638
Abstract
Membrane proteins are inherently amphipathic and undergo dynamic conformational changes for proper function within native membranes. Maintaining the functional structures of these biomacromolecules in aqueous media is necessary for structural studies but difficult to achieve with currently available tools, thus necessitating the development of novel agents with favorable properties. This study introduces several new glucose-neopentyl glycol (GNG) amphiphiles and reveals some agents that display favorable behaviors for the solubilization and stabilization of a large, multi-subunit membrane protein assembly. Furthermore, a detergent structure-property relationship that could serve as a useful guideline for the design of novel amphiphiles is discussed.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/asia.201301303http://hdl.handle.net/20.500.11754/49342
ISSN
1861-4728
DOI
10.1002/asia.201301303
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > ETC
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