Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 전대원 | - |
dc.date.accessioned | 2018-03-20T02:05:00Z | - |
dc.date.available | 2018-03-20T02:05:00Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | Gut Liver, 8, 2, 140?147. | en_US |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964263/ | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/49326 | - |
dc.description.abstract | Background/Aims: DA-9701, a standardized extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that exhibits an analgesic effect on the abdomen. We investigated whether DA-9701 affects visceral pain induced by colorectal distension (CRD) in rats. Methods: A total of 21 rats were divided into three groups: group A (no CRD+no drug), group B (CRD+no drug), and group C (CRD+DA-9701). Expression of pain-related factors, substance P (SP), c-fos, and phosphorylated extracellular signal-regulated kinase (p-ERK) in the dorsal root ganglion (DRG) and spinal cord was determined by immunohistochemical staining and Western blotting. Results: The proportions of neurons in the DRG and spinal cord expressing SP, c-fos, and p-ERK were higher in group B than in group A. In the group C, the proportion of neurons in the DRG and spinal cord expressing p-ERK was lower than that in group B. Western blot results for p-ERK in the spinal cord indicated a higher level of expression in group B than in group A and a lower level of expression in group C than in group B. Conclusions: DA-9701 may decrease visceral pain via the downregulation of p-ERK in the DRG and spinal cord. | en_US |
dc.description.sponsorship | This study was supported by Dong-A Pharmaceutical Company, Seoul, Korea, the manufacturer of DA-9701. The funding source had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | EDITORIAL OFFICE GUT & LIVER, 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL, 135-839, SOUTH KOREA | en_US |
dc.subject | DA-9701 | en_US |
dc.subject | Gastrointestinal diseases | en_US |
dc.subject | Visceral hypersensitivity | en_US |
dc.subject | Colorectal distension | en_US |
dc.subject | Phosphorylated extracellular signal-regulated kinase | en_US |
dc.title | Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.5009/gnl.2014.8.2.140 | - |
dc.relation.page | 140-147 | - |
dc.relation.journal | GUT AND LIVER | - |
dc.contributor.googleauthor | Lee, Sang Pyo | - |
dc.contributor.googleauthor | Lee, Kang Nyeong | - |
dc.contributor.googleauthor | Lee, Oh Young | - |
dc.contributor.googleauthor | Lee, Hang Lak | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Yoon, Byung Chul | - |
dc.contributor.googleauthor | Choi, Ho Soon | - |
dc.contributor.googleauthor | Hwang, Se Jin | - |
dc.contributor.googleauthor | Lee, Seo Eun | - |
dc.relation.code | 2014030230 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | noshin | - |
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