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dc.contributor.author소홍윤-
dc.date.accessioned2018-03-19T08:16:15Z-
dc.date.available2018-03-19T08:16:15Z-
dc.date.issued2014-11-
dc.identifier.citationACS APPLIED MATERIALS & INTERFACES, 권: 6, 호: 23, 페이지: 20693-20699en_US
dc.identifier.issn1944-8244-
dc.identifier.urihttps://pubs.acs.org/doi/abs/10.1021/am506153y-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/49078-
dc.description.abstractThis paper describes a handheld device that uses an all-in-one membrane for continuous mechanical cell lysis and rapid DNA isolation without the assistance of power sources, lysis reagents, and routine centrifugation. This nanowire-decorated multifunctional membrane was fabricated to isolate DNA by selective adsorption to silica surface immediately after disruption of nucleus membranes by ultrasharp tips of nanowires for a rapid cell lysis, and it can be directly assembled with commercial syringe filter holders. The membrane was fabricated by photoelectrochemical etching to create microchannel arrays followed by hydrothermal synthesis of nanowires and deposition of silica. The proposed membrane successfully purifies high-quality DNA within 5 min, whereas a commercial purification kit needs more than an hour.en_US
dc.description.sponsorshipThis work was partially supported by the grants from the KAUST Global Collaborative Research under the Academic Excellence Alliance program, the National Heart Lung and Blood Institute of the NIH as a Program of Excellence in the Nanotechnology award (HHSN268201000043C), RO1HL096796-02, and RO1AI088023-03. The authors are also grateful for support from Marvell Nanolab and Biomolecular Nanotechnology Center at UC Berkeley where all devices were fabricated. H.S. greatly acknowledges Prof. Young Ho Seo at Kangwon National University in Korea for his valuable discussion.en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USAen_US
dc.subjectnanowiresen_US
dc.subjectporous silicon membraneen_US
dc.subjectcell lysisen_US
dc.subjectDNA purificationen_US
dc.subjectpoint-of-care diagnosticsen_US
dc.titleAll-in-One Nanowire-Decorated Multifunctional Membrane for Rapid Cell Lysis and Direct DNA Isolationen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/am506153y-
dc.relation.journalACS APPLIED MATERIALS & INTERFACES-
dc.contributor.googleauthorSo, Ho-
dc.contributor.googleauthorLee, Kun-woo-
dc.contributor.googleauthorMurthy, Niren-
dc.contributor.googleauthorPisano, Albert P-
dc.relation.code2014023980-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF MECHANICAL ENGINEERING-
dc.identifier.pidhyso-
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COLLEGE OF ENGINEERING[S](공과대학) > MECHANICAL ENGINEERING(기계공학부) > Articles
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