223 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author배상철-
dc.date.accessioned2018-03-19T07:23:12Z-
dc.date.available2018-03-19T07:23:12Z-
dc.date.issued2012-04-
dc.identifier.citationGENES AND IMMUNITY, Apr 2012, 13(3), P.232-238en_US
dc.identifier.issn1466-4879-
dc.identifier.urihttps://www.nature.com/articles/gene201182-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/49019-
dc.description.abstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N ¼ 579) and African-Americans (AAs) (N ¼ 407). Multiple peaks of association exceeding a Bonferroni corrected P-value of Po2.03 103 were observed between LN and MYH9 in EAs (N ¼ 4620), with the most pronounced association at rs2157257 (P ¼ 4.7 104, odds ratio (OR) ¼ 1.205). A modest effect with MYH9 was also detected in Gullah (rs8136069, P ¼ 0.0019, OR ¼ 2.304). No association between LN and MYH9 was found in AAs, Asians, Amerindians or Hispanics. This study provides the first investigation of MYH9 in LN in non-Africans and of APOL1 in LN in any population, and presents novel insight into the potential role of MYH9 in LN in EAs.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectMYH9en_US
dc.subjectAPOL1en_US
dc.subjectlupus nephritisen_US
dc.subjectsystemic lupusen_US
dc.subjecterythematosusen_US
dc.subjectmultiethnic association studyen_US
dc.titleRole of MYH9 and APOL1 in African and non-African populations with lupus nephritisen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume13-
dc.identifier.doi10.1038/gene.2011.82-
dc.relation.page232-238-
dc.relation.journalGENES AND IMMUNITY-
dc.contributor.googleauthorLin, C. P.-
dc.contributor.googleauthorAdrianto, I.-
dc.contributor.googleauthorLessard, C. J.-
dc.contributor.googleauthorKelly, J. A.-
dc.contributor.googleauthorKaufman, K. M.-
dc.contributor.googleauthorGuthridge, J. M.-
dc.contributor.googleauthorFreedman, B. I.-
dc.contributor.googleauthorAnaya, J. M.-
dc.contributor.googleauthorAlarcon-Riquelme, M. E.-
dc.contributor.googleauthorPons-Estel, B. A.-
dc.relation.code2012203385-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE