Intractable pneumococcal meningoencephalitis associated with a TNF-alpha antagonist
- Title
- Intractable pneumococcal meningoencephalitis associated with a TNF-alpha antagonist
- Author
- 김현영
- Keywords
- Streptococcus pneumoniae; Meningoencephalitis; TNF-alpha antagonist; Infliximab; White matter; Bacterial meningitis; WHITE-MATTER LESIONS; STREPTOCOCCUS-PNEUMONIAE; BACTERIAL-MENINGITIS; INFLIXIMAB; DISORDERS; INJURY; RISK
- Issue Date
- 2014-09
- Publisher
- ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
- Citation
- Journal of the Neurological Sciences, 2014, 344(1~2), P.215-218
- Abstract
- A 34-year-old man was treated with a TNF-alpha antagonist for ankylosing spondylitis, and this subsequently developed a CNS infection. Magnetic resonance imaging showed diffuse subcortical white matter lesions. Streptococcus pneumoniae was cultured from the cerebrospinal fluid and blood. The patient died of multifocal widespread brain damage and subarachnoid hemorrhage, despite intensive antibacterial medication. Pneumococcal meningoencephalitis can occur in association with TNF-alpha antagonists. Clinicians should be aware of both the risk of fatal bacterial meningoencephalitis associated with TNF-alpha antagonists and the possibility of an unusual presentation of bacterial meningitis. (C) 2014 Published by Elsevier B.V.
- URI
- http://www.sciencedirect.com/science/article/pii/S0022510X14003281http://hdl.handle.net/20.500.11754/48971
- ISSN
- 0022-510X; 1878-5883
- DOI
- 10.1016/j.jns.2014.05.038
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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