172 0

Manipulation of P2X Receptor Activities by Light Stimulation

Title
Manipulation of P2X Receptor Activities by Light Stimulation
Author
김상성
Keywords
OPTICAL CONTROL; FUNCTIONAL-PROPERTIES; GOLD NANOPARTICLES; REMOTE-CONTROL; ION CHANNELS; ATP; NEURONS; LOCALIZATION; INFLAMMATION; NOCICEPTION
Issue Date
2016-01
Publisher
HINDAWI PUBLISHING CORP
Citation
MEDIATORS OF INFLAMMATION, V. 2016, Article ID 7852168
Abstract
P2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS. Control of P2X activation has significant importance in managing unwanted hypersensitive neuron responses. To overcome the limitations of chemical ligand treatment, optical stimulation methods of optogenetics and photoswitching achieve efficient control of P2X activation while allowing specificity at the target site and convenient stimulation by light illumination. There are many potential applications for photosensitive elements, such as improved uncaging methods, photoisomerizable ligands, photoswitches, and gold nanoparticles. Each technique has both advantages and downsides, and techniques are selected according to the purpose of the application. Technical advances not only provide novel approaches to manage inflammation or pain mediated by P2X receptors but also suggest a similar approach for controlling other ion channels.
URI
https://www.hindawi.com/journals/mi/2016/7852168/abs/http://hdl.handle.net/20.500.11754/48912
ISSN
0962-9351; 1466-1861
DOI
10.1155/2016/7852168
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > ETC
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE