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dc.contributor.author최한곤-
dc.date.accessioned2018-03-19T04:30:18Z-
dc.date.available2018-03-19T04:30:18Z-
dc.date.issued2016-01-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 497, No. 1-2, Page. 268-276en_US
dc.identifier.issn0378-5173-
dc.identifier.issn1873-3476-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517315304051-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/48824-
dc.description.abstractAlbumin is considered an attractive dug carrier for hydrophobic drugs to target inflamed joints of rheumatoid arthritis. This study focused on the pharmaceutical potential of albumin-based nanoparticles (NPs) on delivery of tacrolimus (TAC) to enhance targetability and anti-arthritic efficacy. TAC-loaded human serum albumin (HSA) nanoparticles (TAC HSA-NPs) were prepared using the nab (TM) technology. The resulting NPs were 185.8 +/- 6.8 nm in diameter and had a zeta potential value of -30.5 +/- 1.1 mV, as determined by dynamic light scattering. Particles were uniformly spherical in shape as determined by transmission electron microscopy. The encapsulation efficacy of TAC was 79.3 +/- 3.7% and the water solubility was over 46 times greater than that of free TAC. TAC was gradually released from NPs over 24 h, which is sufficient time for targeting and treatment of the NPs in inflamed arthritis via intravenous injection. In vitro study using splenocytes excised from spleens of mice following induction of arthritis using collagen clearly demonstrated the anti-proliferative activity of TAC HSA-NPs on activated T cells compared with non-activated T cells. Furthermore, TAC HSA-NPs displayed significantly more anti-arthritic activity than TAC formulations including intravenously administered TAC solution or oral TAC suspension, as reflected by the incidence of arthritis and clinical score (1.6 vs. 3.2 and 5.0, respectively). These improvements were due to the targetability of HSA that facilitated the accumulation of TAC HSANPs at inflamed arthritis sites. TAC HSA-NPs are a promising drug delivery system to enhance water solubility and increase accumulation in joints for treatment of rheumatoid arthritis. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT, and future Planning (#2014002133).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectAlbuminen_US
dc.subjectNanoparticlesen_US
dc.subjectTacrolimusen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectCollagen-induced arthritisen_US
dc.subjectTargetingen_US
dc.subjectCOLLAGEN-INDUCED ARTHRITISen_US
dc.subjectAPOPTOSIS-INDUCING LIGANDen_US
dc.subjectDRUG-DELIVERY SYSTEMSen_US
dc.subjectT-CELLen_US
dc.subjectANTITUMOR-ACTIVITYen_US
dc.subjectCANCERen_US
dc.subjectEFFICACYen_US
dc.subjectTRAILen_US
dc.subjectFK506en_US
dc.subjectMETHOTREXATEen_US
dc.titlePharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissuesen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume497-
dc.identifier.doi10.1016/j.ijpharm.2015.12.004-
dc.relation.page268-276-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorThao, Le Quang-
dc.contributor.googleauthorByeon, Hyeong Jun-
dc.contributor.googleauthorLee, Changkyu-
dc.contributor.googleauthorLee, Seunghyun-
dc.contributor.googleauthorLee, Eun Seong-
dc.contributor.googleauthorChoi, Han-Gon-
dc.contributor.googleauthorPark, Eun-Seok-
dc.contributor.googleauthorYoun, Yu Seok-
dc.relation.code2016002676-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > ETC
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