Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles
- Title
- Adsorption and desorption of tyrosine kinase inhibitor erlotinib on gold nanoparticles
- Author
- 주재범
- Keywords
- Raman spectroscopy; Erlotinib; Gold nanoparticles; Interfacial structures; Density functional theory
- Issue Date
- 2014-07
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
- Citation
- Journal of colloid and interface science,v.425,pp.96 - 101
- Abstract
- We investigated interfacial behaviors of erlotinib (EL) on gold nanoparticles (AuNPs) by means of Raman spectroscopy. The adsorption reactions and structures of EL on AuNP surfaces were examined by UV-Vis absorption spectroscopy and surface-enhanced Raman scattering (SERS). Density functional theory calculations were performed to estimate the energetic stabilities of the drug-AuNP composites. Among the binding units in EL, the acetylenic C equivalent to C group was calculated to be the most strongly binding on the AuNP cluster atoms, consistent with the SERS spectra. The concentration-dependent SERS spectra indicated that similar to 10(-5) M of EL exhibited the highest SERS signals. The attached EL appeared to desorb more efficiently with 2 mM glutathione than with cell culture media. The lack of a strong SERS signal of EL in the darkfield microscopy images of AuNP-EL complexes suggested almost complete desorption of EL inside cells. (C) 2014 Elsevier Inc. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S0021979714001593http://hdl.handle.net/20.500.11754/48749
- ISSN
- 0021-9797; 1095-7103
- DOI
- 10.1016/j.jcis.2014.03.032
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > ETC
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