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Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers

Title
Real time shear wave elastography in chronic liver diseases: Accuracy for predicting liver fibrosis, in comparison with serum markers
Author
김태엽
Keywords
Elastography; Liver fibrosis; Liver stiffness; Liver biopsy; Serum markers
Issue Date
2014-10
Publisher
Baishideng Publishing Group INC
Citation
World Journal of Gastroenterology, 2014, 20(38) P.13920-13929
Abstract
AIM: To evaluate the correlation between liver stiffness measurement (LSM) by real-time shear wave elastography (SWE) and liver fibrosis stage and the accuracy of LSM for predicting significant and advanced fibrosis, in comparison with serum markers.METHODS: We consecutively analyzed 70 patients with various chronic liver diseases. Liver fibrosis was staged from F0 to F4 according to the Batts and Ludwig scoring system. Significant and advanced fibrosis was defined as stage F >= 2 and F >= 3, respectively. The accuracy of prediction for fibrosis was analyzed using receiver operating characteristic curves.RESULTS: Seventy patients, 15 were belonged to F0-F1 stage, 20 F2, 13 F3 and 22 F4. LSM was increased with progression of fibrosis stage (F0-F1: 6.77 +/- 1.72, F2: 9.98 +/- 3.99, F3: 15.80 +/- 7.73, and F4: 22.09 +/- 10.09, P < 0.001). Diagnostic accuracies of LSM for prediction of F >= 2 and F >= 3 were 0.915 (95%CI: 0.824-0.968, P < 0.001) and 0.913 (95%CI: 0.821-0.967, P < 0.001), respectively. The cut-off values of LSM for prediction of F >= 2 and F >= 3 were 8.6 kPa with 78.2% sensitivity and 93.3% specificity and 10.46 kPa with 88.6% sensitivity and 80.0% specificity, respectively. However, there were no significant differences between LSM and serum hyaluronic acid and type. collagen in diagnostic accuracy.CONCLUSION: SWE showed a significant correlation with the severity of liver fibrosis and was useful and accurate to predict significant and advanced fibrosis, comparable with serum markers. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
URI
https://www.wjgnet.com/1007-9327/full/v20/i38/13920.htm
ISBN
2219-2840
ISSN
1007-9327
DOI
10.3748/wjg.v20.i38.13920
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RESEARCH INSTITUTE[S](부설연구소) > ETC
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