145 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author정승준-
dc.date.accessioned2018-03-17T01:13:01Z-
dc.date.available2018-03-17T01:13:01Z-
dc.date.issued2012-08-
dc.identifier.citationThe Korean journal of physiology & pharmacology, 2012, 16(4), P.237-241, 5P.en_US
dc.identifier.issn0372-1582-
dc.identifier.issn0377-9459-
dc.identifier.issn1226-4512-
dc.identifier.issn2093-3827-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2012.16.5.367-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/48164-
dc.description.abstractIn this study, we determined mode of action of a novel carbamoyloxy arylalkanoyl arylpiperazine compound (SKL-NP) on hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents ($I_h$) that plays important roles in neuropathic pain. In small or medium-sized dorsal root ganglion (DRG) neurons (< $40{\mu}m$ in diameter) exhibiting tonic firing and prominent $I_h$, SKL-NP inhibited $I_h$ and spike firings in a concentration dependent manner ($IC_{50}=7.85{\mu}M$). SKL-NP-induced inhibition of $I_h$ was blocked by pretreatment of pertussis toxin (PTX) and N-ethylmaleimide (NEM) as well as 8-Br-cAMP, a membrane permeable cAMP analogue. These results suggest that SKL-NP modulates $I_h$ in indirect manner by the activation of a Gi-protein coupled receptor that decreases intracellular cAMP concentration. Taken together, SKL-NP has the inhibitory effect on HCN channel currents ($I_h$) in DRG neurons of rats.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-201000000000283).en_US
dc.language.isoenen_US
dc.publisherThe Korean Society of Pharmacologyen_US
dc.subjectcAMP,en_US
dc.subjectGi-protein,en_US
dc.subjectHyperpolarization-activated cyclic nucleotide-gated channelen_US
dc.subjectIhen_US
dc.subjectNeuropathic painen_US
dc.titleA Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neuronsen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume16-
dc.identifier.doi10.4196/kjpp.2012.16.5.367-
dc.relation.page237-241-
dc.relation.journalKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY-
dc.contributor.googleauthorChung, Ge-hoon-
dc.contributor.googleauthorKim, Tae-Hyung-
dc.contributor.googleauthorShin, Hye-won-
dc.contributor.googleauthorChae, Eun-hee-
dc.contributor.googleauthorYi, Han-ju-
dc.contributor.googleauthorMoon, Hong-sik-
dc.contributor.googleauthorKim, Hyun-Jin-
dc.contributor.googleauthorKim, Joong-Soo-
dc.contributor.googleauthorJung, Sung-Jun-
dc.contributor.googleauthorOh, Seog-Bae-
dc.relation.code2012217915-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE