Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정승준 | - |
dc.date.accessioned | 2018-03-17T01:13:01Z | - |
dc.date.available | 2018-03-17T01:13:01Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | The Korean journal of physiology & pharmacology, 2012, 16(4), P.237-241, 5P. | en_US |
dc.identifier.issn | 0372-1582 | - |
dc.identifier.issn | 0377-9459 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.issn | 2093-3827 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2012.16.5.367 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/48164 | - |
dc.description.abstract | In this study, we determined mode of action of a novel carbamoyloxy arylalkanoyl arylpiperazine compound (SKL-NP) on hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents ($I_h$) that plays important roles in neuropathic pain. In small or medium-sized dorsal root ganglion (DRG) neurons (< $40{\mu}m$ in diameter) exhibiting tonic firing and prominent $I_h$, SKL-NP inhibited $I_h$ and spike firings in a concentration dependent manner ($IC_{50}=7.85{\mu}M$). SKL-NP-induced inhibition of $I_h$ was blocked by pretreatment of pertussis toxin (PTX) and N-ethylmaleimide (NEM) as well as 8-Br-cAMP, a membrane permeable cAMP analogue. These results suggest that SKL-NP modulates $I_h$ in indirect manner by the activation of a Gi-protein coupled receptor that decreases intracellular cAMP concentration. Taken together, SKL-NP has the inhibitory effect on HCN channel currents ($I_h$) in DRG neurons of rats. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-201000000000283). | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Korean Society of Pharmacology | en_US |
dc.subject | cAMP, | en_US |
dc.subject | Gi-protein, | en_US |
dc.subject | Hyperpolarization-activated cyclic nucleotide-gated channel | en_US |
dc.subject | Ih | en_US |
dc.subject | Neuropathic pain | en_US |
dc.title | A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 16 | - |
dc.identifier.doi | 10.4196/kjpp.2012.16.5.367 | - |
dc.relation.page | 237-241 | - |
dc.relation.journal | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.contributor.googleauthor | Chung, Ge-hoon | - |
dc.contributor.googleauthor | Kim, Tae-Hyung | - |
dc.contributor.googleauthor | Shin, Hye-won | - |
dc.contributor.googleauthor | Chae, Eun-hee | - |
dc.contributor.googleauthor | Yi, Han-ju | - |
dc.contributor.googleauthor | Moon, Hong-sik | - |
dc.contributor.googleauthor | Kim, Hyun-Jin | - |
dc.contributor.googleauthor | Kim, Joong-Soo | - |
dc.contributor.googleauthor | Jung, Sung-Jun | - |
dc.contributor.googleauthor | Oh, Seog-Bae | - |
dc.relation.code | 2012217915 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | eurijj | - |
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