Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤병철 | - |
dc.date.accessioned | 2018-03-16T08:50:09Z | - |
dc.date.available | 2018-03-16T08:50:09Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2014, 446(4), P.822-829 | en_US |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0006291X14003349 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/48150 | - |
dc.description.abstract | Obesity is associated with certain types of cancer, including gastric cancer. However, it is still unclear whether obesity-related cytokine, leptin, is implicated in gastric cancer. Therefore, we aimed to investigate the role of leptin in gastric cancer. The expression of leptin and its receptor, Ob-R, was assessed by immunohistochemical staining and was compared in patients with gastric adenoma (n = 38), early gastric cancer (EGC) (n = 38), and advanced gastric cancer (AGC) (n = 38), as a function of their clinicopathological characteristics. Gastric cancer cell lines were studied to investigate the effects of leptin on the signal transducer and activator of transcription-3 (STAT3) and extracellular receptor kinase 1/2 (ERK1/2) signaling pathways using MTI' assays, immunoblotting, and inhibition studies. Leptin was expressed in gastric adenomas (42.1%), EGCs (47.4%), and AGCs (43.4%). Ob-R expression tended to increase from gastric adenoma (2%), through EGC (8%), to AGC (18%). Leptin induced the proliferation of gastric cancer cells by activating STAT3 and ERK1/2 and up-regulating the expression of vascular endothelial growth factor (VEGF). Blocking Ob-R with pharmacological inhibitors and by RNAi decreased both the leptin-induced activation of STAT3 and ERK1/2 and the.leptin-induced expression of VEGF. Leptin plays a role in gastric cancer by stimulating the proliferation of gastric cancer cells via activating the STAT3 and ERK1/2 pathways. (C) 2014 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2011-MC). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science | en_US |
dc.subject | Leptin | en_US |
dc.subject | Leptin receptor | en_US |
dc.subject | Gastric cancer | en_US |
dc.title | The role of leptin in gastric cancer: Clinicopathologic features and molecular mechanisms | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 446 | - |
dc.identifier.doi | 10.1016/j.bbrc.2014.02.072 | - |
dc.relation.page | 822-829 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.googleauthor | Lee, K. N. | - |
dc.contributor.googleauthor | Choi, H. S. | - |
dc.contributor.googleauthor | Yang, S. Y. | - |
dc.contributor.googleauthor | Park, H. K. | - |
dc.contributor.googleauthor | Lee, Y. Y. | - |
dc.contributor.googleauthor | Lee, O. Y. | - |
dc.contributor.googleauthor | Yoon, B. C. | - |
dc.contributor.googleauthor | Hahm, J. S. | - |
dc.contributor.googleauthor | Paik, S. S. | - |
dc.relation.code | 2014026012 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yoonbc | - |
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