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dc.contributor.author최호순-
dc.date.accessioned2018-03-16T08:47:28Z-
dc.date.available2018-03-16T08:47:28Z-
dc.date.issued2014-04-
dc.identifier.citationBiochemical and Biophysical Research Communications, 2014, 446(4), P.822-829en_US
dc.identifier.issn0006-291X-
dc.identifier.issn1090-2104-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0006291X14003349-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/48147-
dc.description.abstractObesity is associated with certain types of cancer, including gastric cancer. However, it is still unclear whether obesity-related cytokine, leptin, is implicated in gastric cancer. Therefore, we aimed to investigate the role of leptin in gastric cancer. The expression of leptin and its receptor, Ob-R, was assessed by immunohistochemical staining and was compared in patients with gastric adenoma (n = 38), early gastric cancer (EGC) (n = 38), and advanced gastric cancer (AGC) (n = 38), as a function of their clinicopathological characteristics. Gastric cancer cell lines were studied to investigate the effects of leptin on the signal transducer and activator of transcription-3 (STAT3) and extracellular receptor kinase 1/2 (ERK1/2) signaling pathways using MTI' assays, immunoblotting, and inhibition studies. Leptin was expressed in gastric adenomas (42.1%), EGCs (47.4%), and AGCs (43.4%). Ob-R expression tended to increase from gastric adenoma (2%), through EGC (8%), to AGC (18%). Leptin induced the proliferation of gastric cancer cells by activating STAT3 and ERK1/2 and up-regulating the expression of vascular endothelial growth factor (VEGF). Blocking Ob-R with pharmacological inhibitors and by RNAi decreased both the leptin-induced activation of STAT3 and ERK1/2 and the.leptin-induced expression of VEGF. Leptin plays a role in gastric cancer by stimulating the proliferation of gastric cancer cells via activating the STAT3 and ERK1/2 pathways. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2011-MC).en_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.subjectLeptinen_US
dc.subjectLeptin receptoren_US
dc.subjectGastric canceren_US
dc.titleThe role of leptin in gastric cancer: Clinicopathologic features and molecular mechanismsen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume446-
dc.identifier.doi10.1016/j.bbrc.2014.02.072-
dc.relation.page822-829-
dc.relation.journalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.contributor.googleauthorLee, K. N.-
dc.contributor.googleauthorChoi, H. S.-
dc.contributor.googleauthorYang, S. Y.-
dc.contributor.googleauthorPark, H. K.-
dc.contributor.googleauthorLee, Y. Y.-
dc.contributor.googleauthorLee, O. Y.-
dc.contributor.googleauthorYoon, B. C.-
dc.contributor.googleauthorHahm, J. S.-
dc.contributor.googleauthorPaik, S. S.-
dc.relation.code2014026012-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhschoi96-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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