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dc.contributor.author윤태현-
dc.date.accessioned2018-03-16T06:52:36Z-
dc.date.available2018-03-16T06:52:36Z-
dc.date.issued2014-02-
dc.identifier.citationBULLETIN OF THE KOREAN CHEMICAL SOCIETY; FEB 10 2014, 35, 2, p365-p370en_US
dc.identifier.issn0253-2964-
dc.identifier.urihttp://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2014_v35n2_365-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/48012-
dc.description.abstractFor real-time monitoring of colloidal nanoparticles (NPs) in aqueous media, a light sheet type dark-field microscopy system combined with a microfluidic concentration gradient generator (mu FCGG-LSDFM) was developed. Various concentrations of colloidal Au NPs were simultaneously generated with the iFCGG and characterized with the LSDFM setup. The number concentrations and hydrodynamic size distributions were measured via particle counting and tracking analysis (PCA and PTA, respectively) approaches. For the 30 nm Au NPs used in this study, the lower detection limit of the LSDFM setup was 3.6 ng/mL, which is about 400 times better than that of optical density measurements under the same mu FCGG system. Additionally, the hydrodynamic diameter distribution of Au NPs was estimated as 39.7 +/- 12.2 nm with the PTA approach, which agrees well with DLS measurement as well as the manufacturer's specification. We propose this mu FCGG-LSDFM setup with features of automatic generation of NP concentration gradient and real-time monitoring of their physicochemical characteristics (e.g., number concentration, and hydrodynamic size distribution) as an important component of future high-throughput screening or high-content analysis platforms of nanotoxicity.en_US
dc.description.sponsorshipThis work was supported by the R&D Program (10043929, Development of “User-friendly Nanosafety Prediction System”) funded by the Ministry of Trade, Industry, & Energy (MOTIE, Korea).en_US
dc.language.isoenen_US
dc.publisherKOREAN CHEMICAL SOC, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL 135-703, SOUTH KOREAen_US
dc.subjectLight sheet dark-field microscopyen_US
dc.subjectMicrofluidic concentration gradient deviceen_US
dc.subjectParticle tracking analysisen_US
dc.subjectReal-time monitoringen_US
dc.subjectColloidal nanoparticlesen_US
dc.titleReal-time Monitoring of Colloidal Nanoparticles using Light Sheet Dark-field Microscopy Combined with Microfluidic Concentration Gradient Generator (mu FCGG-LSDFM)en_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume35-
dc.identifier.doi10.5012/bkcs.2014.35.2.365-
dc.relation.page365-370-
dc.relation.journalBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.contributor.googleauthorChoe, Hyeokmin-
dc.contributor.googleauthorNho, Hyun Woo-
dc.contributor.googleauthorPark, Jonghoon-
dc.contributor.googleauthorKim, Jin Bae-
dc.contributor.googleauthorYoon, Tae Hyun-
dc.relation.code2014026628-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF CHEMISTRY-
dc.identifier.pidtaeyoon-
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COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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