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dc.contributor.author신수진-
dc.date.accessioned2018-03-16T05:22:28Z-
dc.date.available2018-03-16T05:22:28Z-
dc.date.issued2014-06-
dc.identifier.citationJOURNAL OF BREAST CANCER, 권: 17, 호: 2, 페이지: 113-120en_US
dc.identifier.issn1738-6756-
dc.identifier.issn2092-9900-
dc.identifier.urihttps://synapse.koreamed.org/search.php?where=aview&id=10.4048/jbc.2014.17.2.113&code=0096JBC&vmode=FULL-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47868-
dc.description.abstractPurpose: Insulin-like growth factor 1 receptor (IGF-1R) is commonly expressed in primary breast cancers. Understanding the role of IGF-1R signaling in the different subtypes of breast cancer is important because each subtype has a different outcome and requires different treatment modalities. However, the precise biological significance of IGF-1R expression in cancer cells is still unclear. In this study, we examined the expression of IGF-1R in the different molecular subtypes of breast cancer. The effects of IGF-1R expression on the survival rates and outcomes of breast cancer were also examined. Methods: IGF-1R expression was evaluated immunohistochemically in tissue microarray blocks constructed from 1,198 invasive breast cancer samples collected from six medical institutions. IGF-1R expression was interpreted according to the human epidermal growth factor receptor 2 (HER2)/neu immunohistochemistry scoring system. Scores of 2+ and 3+ were considered positive. Results: Positive IGF-1R expression was observed in 65.4% of invasive breast cancer samples. IGF-1R expression was detected in all cancer subtypes (luminal A, 84.4%; luminal B, 75.9%; HER2, 21.2%; triple-negative, 46.6%) and was found to be associated with a positive hormone receptor status and the absence of HER2 amplification (p<0.001). Positive IGF-1R expression was significantly associated with high survival rates (p=0.014). However, a multivariate analysis revealed that the expression levels of IGF-1R did not achieve statistical significance. In the triple-negative cancer subtype, IGF-1R expression was found to be associated with a lower disease-free survival rate (p=0.031). Conclusion: Positive IGF-1R expression is associated with a favorable prognosis in breast cancer. IGF-1R is frequently expressed in the luminal A/B subtypes of breast cancer, and its expression is related to the hormone receptor status.en_US
dc.language.isoenen_US
dc.publisherKOREAN BREAST CANCER SOC, 163 SINMUNRO 1-GA JONGRO-GU, OFFICIA BUILDING, SUITE 2024, SEOUL, 110-999, SOUTH KOREAen_US
dc.subjectBreast neoplasmsen_US
dc.subjectInsulin-like growth factor 1 receptoren_US
dc.subjectImmunohistochemistryen_US
dc.titlePositive Expression of Insulin-Like Growth Factor-1 Receptor Is Associated with a Positive Hormone Receptor Status and a Favorable Prognosis in Breast Canceren_US
dc.typeArticleen_US
dc.relation.volume17-
dc.identifier.doi10.4048/jbc.2014.17.2.113-
dc.relation.page113-120-
dc.relation.journalJOURNAL OF BREAST CANCER-
dc.contributor.googleauthorShin, Su-Jin-
dc.contributor.googleauthorGong, Gyung-yub-
dc.contributor.googleauthorLee, Hee-Jin-
dc.contributor.googleauthorKang, Jun-
dc.contributor.googleauthorBae, Young-Kyung-
dc.contributor.googleauthorLee, Ah-won-
dc.contributor.googleauthorCho, Eun-Yoon-
dc.contributor.googleauthorLee, Ji-Shin-
dc.contributor.googleauthorSuh, Kwang-Sun-
dc.contributor.googleauthorLee, Dong-Wha-
dc.relation.code2014032556-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidcharm-


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