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dc.contributor.author임영효-
dc.date.accessioned2018-03-16T02:56:28Z-
dc.date.available2018-03-16T02:56:28Z-
dc.date.issued2014-01-
dc.identifier.citationBMC NEUROLOGY; JAN 12, 2014, 14, 7p.en_US
dc.identifier.issn1471-2377-
dc.identifier.urihttps://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-14-8-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/47730-
dc.description.abstractBackground: Abnormalities in nocturnal blood pressure dipping are well known for its relationship to cardiovascular diseases. Cerebral microbleeds are frequently observed in patients with hypertension and are known to be potent risk factors for stroke. However, there are scanty reports about the relationship between nocturnal dipping and cerebral microbleeds. Methods: We recruited consecutive patients with both hypertension and ischemic stroke within 7 days after symptom onset, and those with cardioembolism were excluded. We applied 24-hour ambulatory blood pressure monitoring two weeks after stroke onset, and we used brain MRI to detect cerebral microbleeds. Various blood pressure parameters such as mean 24-hour blood pressure, awake/sleep blood pressure, and morning surge were compared between cerebral microbleeds (+) vs. (-) groups. Subjects were further classified according to nocturnal dipping status and were analyzed by logistic regression to determine its association with cerebral microbleeds with adjustment for age, gender, and cardiovascular risk factors. Results: A total of 162 patients (100 males, age 65.33 +/- 10.32 years) were included. Cerebral microbleeds were detected in 65 patients (40.1%). Most ambulatory blood pressure parameters except morning surge were significantly higher in those who had cerebral microbleeds. After adjusting for the confounding factors, the reverse dippers were prone to have cerebral microbleeds (odds ratio, 3.81; 95% confidential interval, 1.36-10.65; p-value = 0.01). Conclusion: Cerebral microbleeds are independently associated with reverse dipping on ambulatory blood pressure monitoring in hypertensive stroke patients.en_US
dc.description.sponsorshipThis study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. (A101311) The funding organizations did not participate in the design, conduct, or analysis of the study or in the preparation of this report.en_US
dc.language.isoenen_US
dc.publisherBIOMED CENTRAL LTDen_US
dc.subjectAmbulatory blood pressure monitoringen_US
dc.subjectCerebral microbleedsen_US
dc.subjectCerebrovascular diseaseen_US
dc.subjectCerebral ischemiaen_US
dc.subjectHypertensionen_US
dc.titleCerebral microbleeds are associated with nocturnal reverse dipping in hypertensive patients with ischemic strokeen_US
dc.typeArticleen_US
dc.relation.volume14-
dc.identifier.doi10.1186/1471-2377-14-8-
dc.relation.page1-7-
dc.relation.journalBMC NEUROLOGY-
dc.contributor.googleauthorKim, Young Seo-
dc.contributor.googleauthorMoon, Jangsup-
dc.contributor.googleauthorKwon, Hyung-Min-
dc.contributor.googleauthorLim, Jae-Sung-
dc.contributor.googleauthorMoon, Jangsup-
dc.contributor.googleauthorPark, Hyeri-
dc.contributor.googleauthorNam, Hyunwoo-
dc.contributor.googleauthorKim, Hyun Young-
dc.contributor.googleauthorLim, Young-Hyo-
dc.relation.code2014026324-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidmdoim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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