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dc.contributor.author김계성-
dc.date.accessioned2018-03-16T02:44:22Z-
dc.date.available2018-03-16T02:44:22Z-
dc.date.issued2014-06-
dc.identifier.citationJOURNAL OF DENTAL RESEARCH, 2014, 93(6), P.571-575en_US
dc.identifier.issn0022-0345-
dc.identifier.issn1544-0591-
dc.identifier.urihttp://journals.sagepub.com/doi/abs/10.1177/0022034514529303?journalCode=jdrb-
dc.description.abstractMicroRNAs (miRNAs) are known to regulate a variety of gene functions in many tissues and organs, but their expression and function in tooth development are not well-understood. A specific miRNA, miR-135a, was determined to be highly expressed at the bud stage. Interestingly, after the cap stage, miR-135a was expressed in the epithelium and mesenchyme but not in the inner enamel epithelium. To identify the relationship between miR-135a and its putative target genes, Bmpr-Ia and Bmpr-Ib, in early tooth development, miR-135a was ectopically overexpressed with a lentivirus. This overexpression resulted in the repression of Bmpr-Ia and Bmpr-Ib. Furthermore, miR-135a inhibited both Bmpr-Ia and Bmpr-Ib transcription. BMP2 proteins were expressed ectopically in tooth germs during the cap stage to determine the relationship between miR-135a and BMP signaling in early tooth development. When miR-135a was ectopically expressed, no tooth formation was observed after 4 wk of incubation in the kidney capsule. This study suggested that Bmp signaling, specifically Bmpr-Ia and Bmpr-Ib, regulates tooth formation via miR-135a.en_US
dc.description.sponsorshipThis study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A101578). The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.subjectmicroRNAen_US
dc.subjectBmp receptorsen_US
dc.subjectmiRNA expressionen_US
dc.subjectlentivirusen_US
dc.subjectmiRNA inhibitoren_US
dc.subjecttooth developmenten_US
dc.titleFailure of Tooth Formation Mediated by miR-135a Overexpression via BMP Signalingen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume93-
dc.identifier.doi10.1177/0022034514529303-
dc.relation.page571-575-
dc.relation.journalJOURNAL OF DENTAL RESEARCH-
dc.contributor.googleauthorKim, E.J-
dc.contributor.googleauthorLee, M.J.-
dc.contributor.googleauthorLi, L.-
dc.contributor.googleauthorYoon, K.S.-
dc.contributor.googleauthorKim, K.S.-
dc.contributor.googleauthorJung, H.S-
dc.relation.code2014032925-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidks66kim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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